Leukotriene B.sub.4 antagonists

Details Leukotriene B.sub.4 antagonists Leukotriene B.sub.4 antagonists

1994-06-08

1996-05-14

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549407, 549405, 546196, C07D40510, C07D31158, C07D31166

Patent

active

055169171

ABSTRACT:
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;

REFERENCES:
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patent: 5124350 (1992-06-01), Djuric et al.
patent: 5380740 (1995-01-01), Djuric et al.
J. Drummond et al. Tetrahedron Letters 29:1653-1656 (1988) "Convenient Procedure for the Preparation of Alkyl and Aryl Substituted N-(Aminoalkylacyl) Sulfonamides".
V. Matassa, et al. J. Med. Chem. 33:1781-1790 (1990) "Evolution of a Series of Peptidoleukotriene Antagonists: Synthesis and Structure/Activity Relationships of 1,3,5-Substituted Indoles and Indazoles".
T. Schaaf, et al. Journal of Medicinal Chemistry 22:1340-1346 (1979) "Synthesis and Biological Activity of Carboxyl-Terminus Modified Prostaglandin Analogues".

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