Leukotriene B.sub.4 antagonists

Details Leukotriene B.sub.4 antagonists Leukotriene B.sub.4 antagonists

1996-02-22

1997-11-04

Chan, Nicky

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

564 91, 564 99, 546226, C07D29510, C07C23308

Patent

active

056841620

ABSTRACT:
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;

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J. Drummond, et al. Tetrahedron Letters 29: 1653-1656 (1988) "Convenient Procedure for the Preparation of Alkyl and Aryl Substituted N-(Aminoalkylacyl) Sulfonamides".
V. Matassa, et al. J. Med. Chem. 33: 1781-1790 (1990) "Evolution of a Series of Peptidoleukotriene Antagonists: Synthesis and Structure/Activity Relationships of 1,3,5-Substituted Indoles and Indazoles".
T. Schaaf, et al. Journal of Medicinal Chemistry 22: 1340-1346 (1979), "Synthesis and Biological Activity of Carboxyl-Terminus Modified Prostaglandin Analogues".

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