Leukotriene antagonists intermediates

Details Leukotriene antagonists intermediates Leukotriene antagonists intermediates

1983-03-07

1985-08-06

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

514826, 560153, 562556, 562557, 562581, 562594, 564153, 564154, 564198, 564199, 564201, C07C14920, C07C14923, A61K 3116, A61K 31185

Patent

active

045337470

ABSTRACT:
The compounds represented by the formula (I) ##STR1## wherein m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; R.sub.1 ' is hydrogen, ##STR2## and R.sub.2 ' is amino, --NHCH.sub.2 CO.sub.2 R.sub.3 ', ##STR3## --NHCH.sub.2 CONH.sub.2 or --OR.sub.3 ' wherein R.sub.3 ' is an alkyl radical containing one to six carbon atoms with the proviso that when m is 0, R.sub.1 ' is hydrogen are chemical intermediates in the synthesis of leukotriene antagonists of the formula (II) ##STR4## wherein m and p, are described above and R.sub.1 is hydrogen, amino or ##STR5## R.sub.2 is hydroxyl, amino, --NHCH.sub.2 CO.sub.2 H, ##STR6## --NHCH.sub.2 CONH.sub.2 ; and X is ##STR7## --CO.sub.2 H or --CH.sub.2 OH which are useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

REFERENCES:
patent: 3873624 (1975-03-01), Mathew et al.
patent: 4130713 (1978-12-01), Baggiolini et al.
patent: 4177277 (1979-12-01), Ondetti et al.

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