Leukotriene antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514538, 514539, 514542, 514562, 514604, 514605, 548253, 560 12, 560 13, 562430, 564 82, A61K 3118, C07C14374, C07C14380

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active

049545132

ABSTRACT:
This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, pharmaceutical compositions containing such compounds, and methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

REFERENCES:
patent: 66588 (1987-06-01), Frazee et al.
patent: 66592 (1987-06-01), Gleason et al.
patent: 4609744 (1986-09-01), Young et al.
Chemical Abstracts, vol. 101, No. 17, p. 718, Abstract 151857q (Oct. 22, 1984).
Patent Abstracts of Japan, vol. 9, No. 306 (C-317) (2029) Dec. 3, 1985.
Derwent Patent Abstract 84-014267/03 of Japanese Patent Application 58206556A published Dec. 1, 1983.
Chemical Abstracts 96(17):143290n.
Chemical Abstracts 94(9):64755y.
Chemical Abstracts, vol. 96, 98909h (1982).
Gleason et al., J. Med. Chem., 30, 6, 959-961 (1987).

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