Leukotriene antagonists

Details Leukotriene antagonists Leukotriene antagonists

1987-10-29

1988-10-04

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514562, 514574, 514616, 562556, 562557, 562581, 562594, 564153, 564154, C07C14920, A61K 31195

Patent

active

047756624

ABSTRACT:
The compounds represented by the formula (I) ##STR1## wherein n is 1 or 2; m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; X is hydrogen or hydroxyl; R is hydroxyl or amino; R.sub.1 is hydrogen, amino or ##STR2## and R.sub.2 is hydroxyl, amino, ##STR3## with the proviso that when m is 0, R.sub.1 is hydrogen or pharmaceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

REFERENCES:
patent: 4176235 (1979-11-01), Ondetti
patent: 4177277 (1979-12-01), Ondetti
patent: 4297275 (1981-10-01), Sundeen
patent: 4461775 (1984-07-01), Stanley
patent: 4469705 (1984-09-01), Stanley
patent: 4513005 (1985-04-01), Baker
Derwent Patent Abstract Bulletin (73260E).
Allinger, "Organic Chemistry", p. 458 (1971).
Drazen, Proc. Natl. Acad. Sc., 78 pp. 3195-3198 (1981).
Derwent Patent Abstract No. 73251 E/35 (1982).

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