Leukotriene antagonists

Details Leukotriene antagonists Leukotriene antagonists

1984-10-17

1987-07-28

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

548252, 549299, 558235, 558413, 558414, 560 21, 560 28, 560 34, 560 45, 560 48, 560 53, 560 56, 562428, 562436, 562439, 562452, 562457, 562462, 562466, C07C14940

Patent

active

046833250

ABSTRACT:
Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

REFERENCES:
patent: 3954852 (1976-05-01), Shen
patent: 4125732 (1978-11-01), McEvay
patent: 4443626 (1984-04-01), Noda
Murch, "Advanced Organic Chemistry; Reactions Mechanisms, and Structure," pp. 357-361 (1968).
D. M. Bailey et al., Ann Rpts. Med. Chem 17 203 (1982).
B. Samuelson, Science, 220 568 (1983).
J. Med. Chem., vol. 20, 371 (1977).

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