Leukotriene antagonists

Details Leukotriene antagonists Leukotriene antagonists

1985-03-20

1987-05-19

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

514826, 514861, 514863, 514886, 558394, 560 9, 560 11, 560 12, 560 45, 560 53, 562429, 562430, 562455, 562463, C07C14940, A61K 3119

Patent

active

046670556

ABSTRACT:
Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 E.sub.4 and the slow reacting substance of anaphylaxis.
As such, these compounds will be useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

REFERENCES:
patent: 3970694 (1976-07-01), Minai et al.
patent: 4008323 (1977-02-01), Cousse et al.
patent: 4133889 (1979-01-01), Augstein et al.
D. M. Bailey et al., Ann. Rpts. Med. Chem. 17 203 (1982).
B. Samuelsson, Science, 220, 568 (1983).

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