Leukotriene antagonists

Details Leukotriene antagonists Leukotriene antagonists

1989-01-03

1991-01-08

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514520, 514522, 514562, 514569, 558412, 558413, 558414, 558415, 558416, 560 10, 560 21, 560 45, 560 46, 560 53, 560 56, 562427, 562428, 562435, 562452, 562462, 562466, A61K 3121

Patent

active

049836285

ABSTRACT:
Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reaction substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

REFERENCES:
patent: 3954852 (1976-05-01), Shen
patent: 4125732 (1978-11-01), McEvay
patent: 4443626 (1984-04-01), Noda
March, "Advanced Organic Chemistry; Reactions Mechanisms, and Structure," pp. 357-361 (1968).
Bailey, Ann. Rpts. Med Chem., 17, p. 203 (1982).
Samuelson, Science, 220, p. 568 (1983).
Appleton, J. Med. Chem., 20, p. 371 (1977).

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