Leukostimulatory agent for in vivo leukocyte tagging

Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 141, 424 149, 424 173, 424 934, 424 935, 424 851, 530300, 530351, 530304, A61K 5108, A61K 3800, A61B 5055

Patent

active

056435495

ABSTRACT:
Methods and reagents for the in vivo tagging of leukocytes, and in particular lymphocytes, with a leukostimulatory agent and a linked medically useful metal ion, including a radioisotope, and subsequent detection of leukocyte or lymphocyte trafficking and sites of concentrated leukocytes or lymphocytes within the patient by radiodetection or paramagnetic means are disclosed.

REFERENCES:
patent: 3812264 (1974-05-01), Nouel
patent: 4289747 (1981-09-01), Chu
patent: 4421735 (1983-12-01), Haber
patent: 4424200 (1984-01-01), Crockford et al.
patent: 4427646 (1984-01-01), Olexa et al.
patent: 4455290 (1984-06-01), Olexa et al.
patent: 4479930 (1984-10-01), Hnatowich
patent: 4485101 (1984-11-01), Coy et al.
patent: 4550086 (1985-10-01), Reinherz et al.
patent: 4622420 (1986-11-01), Meares et al.
patent: 4634586 (1987-01-01), Goodwin et al.
patent: 4668503 (1987-05-01), Hnatowich
patent: 4670545 (1987-06-01), Fritzberg et al.
patent: 4724212 (1988-02-01), Epstein
patent: 4732864 (1988-03-01), Tolman
patent: 4735210 (1988-04-01), Goldenberg
patent: 4810693 (1989-03-01), Pickart
patent: 4853371 (1989-08-01), Coy et al.
patent: 4861579 (1989-08-01), Meyer, Jr. et al.
patent: 4870015 (1989-09-01), Hoffman
patent: 4871717 (1989-10-01), Coy et al.
patent: 4877868 (1989-10-01), Reno et al.
patent: 4904642 (1990-02-01), Coy et al.
patent: 4917878 (1990-04-01), Thakur
patent: 4925648 (1990-05-01), Hansen et al.
patent: 4926869 (1990-05-01), Rubin et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 5002869 (1991-03-01), Schlossman et al.
patent: 5011676 (1991-04-01), Thakur
patent: 5011916 (1991-04-01), Bonnyman et al.
patent: 5023237 (1991-06-01), Pickart
patent: 5053493 (1991-10-01), Pak et al.
patent: 5059588 (1991-10-01), Pickart
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5078985 (1992-01-01), Rhodes
patent: 5079343 (1992-01-01), Anderson et al.
patent: 5089604 (1992-02-01), Washino et al.
patent: 5102990 (1992-04-01), Rhodes
patent: 5116596 (1992-05-01), Bremer et al.
patent: 5120642 (1992-06-01), Schlossman et al.
patent: 5128119 (1992-07-01), Griffiths
patent: 5143712 (1992-09-01), Brandley et al.
patent: 5200178 (1993-04-01), Strauss et al.
patent: 5223426 (1993-06-01), Skibbens et al.
patent: 5225180 (1993-07-01), Dean et al.
patent: 5240693 (1993-08-01), Born et al.
patent: 5317091 (1994-05-01), Subramanian
patent: 5328679 (1994-07-01), Hansen et al.
patent: 5371184 (1994-12-01), Rajagopalan et al.
"Basic and Clinical Immunology", Seventh Edition, Stites and Terr, Chapter 5, p. 614, 1991, Publ. Appleton & Lange.
Albert, et al., Abstract "A Somatostatin Analogue to Image-SS-Receptor-Positive Tumors: . . ." J. Nucl. Med., vol. 31 (1990).
Arnold, et al., "Engineered Metal-Binding Proteins: Purification to Protein Folding," Science, vol. 252, pp. 1796-1797 (Jun. 28, 1991).
Astaldi, et al., "Antibodies to Phytohaemagglutinin," The Lancet, pp. 502-553 (Aug. 27, 1966).
Bakker, et al., "In Vivo Use of a Radioiodinated Somatostatin Analog: Dynamics, Metabolism, and binding to Somatostatin Receptor-Positive Tumors in Man," J. Nucl Med., vol. 32, No. 6, pp. 1184-1191 (1991).
Baker, et al., "Receptor Scintigraphy with a Radioiodinated Somatostatin Analog: Radiolabeling, Purification, Biologic Activity, and In Vivo Application in Animals," J. Nucl. Med., vol. 31, No. 9, pp. 1501-1509 (Sep. 1990).
Baidoo, et al., ".sup.99m Tc Labeling of Proteins: Initial Evaluation of a Novel Diaminedithiol Bifunctional Chelating Agent," Cancer Res. Supp), vol. 50, pp. 799-803 (Apr. 1984).
Bryson, et al., "Neutral Technetium(V) Complexes with Amide-Thiol-Thioether Chelating Ligands," Inorg. Chem., vol. 27, pp. 2154-2161 (1988).
Bryson, et al., "Protecting Groups in the Preparation of Thiolate Complexes of Technetium," Inorg. Chem., vol. 29, pp. 2948-2951 (1990).
Byrd, "Inhibition of the Mitogenic Factor in Phytohaemagglutinin by an Antiserum," Nature, pp. 622-624 (Feb. 1967).
Byrne, et al., "Technetium-99m Bifunctional Chelating Agent-Thiolactone for Coupling to Biomolecules, N.sub.2 N.sub.2 Ligand for Chelation to Technetium," J. Nucl. Med., vol. 24, p. 126 (1983).
Castronovo, et al., "Laminin Receptor Complementary DNA-deduced Synthetic Peptide Inhibits Cancer Cell Attachment to Endothelium," Cancer Res., vol. 51, pp. 5672-5678 (Oct. 1991).
Cioce, et al., "Increased Expression of the Laminin Receptor in Human Colon Cancer," Articles, J. of National Cancer Insti., vol. 83, No. 1, pp. 29-36 (Jan. 1991).
Cox, "Technetium Labeled Somatostatis a Potential Agent for In Vivo Tumor Localization," 7th Int'l Symp. on Radiopharm., p. 16 (1991) Abstract.
Davison, "A New Class of Oxotechnetium (5+) Chelate Complexes Containing a TcON.sub.2 S.sub.2 Core," Amer. Chem Soc., vol. 20, No. 6, pp. 1629-1632 (1981).
Drapeau, "Synthetic C5a Receptor Agonists," Biochem. Pharm., vol. 45, No. 6, pp. 1289-1299 (1993).
El-Hag, et al., "Immunosuppression by Activated Human Neutrophils," J. Immun., vol. 139, No. 7, pp. 2406-2413 (Oct. 1987).
Fischman, et al., "Imaging Focal Sites of Bacterial Infection in Rats with Indium-111-Labeled Chemotactic Peptide Analogs," J. Nucl. Med., vol. 32, No. 3, pp. 483-491 (Mar. 1991).
Fritzberg, et al., "Approaches to Radiolabeling of Antibodies for Diagnosis and Therapy of Cancer," Pharm. Res., vol. 5, No. 6, pp. 325-334 (1988).
Fritzberg, et al., "Synthesis and Biological Evaluation of Tc-99m N,N'-Bis(mercaptoacetyl)-2,3-diaminopropanoate: A Potential Replacement for [.sup.131 ].theta.-iodohippurate," J. Nucl. Med., vol. 23, No. 7, pp. 592-598 (1982).
Ghadiri, et al., "Peptide Architecture. Design of Stable .alpha.-Helical Metallopeptides via a Novel Exchange-Inert RU.sup.III Complex," J. Am. Chem. Soc., vol. 112 pp. 9633-9635 (1990).
Granowska, et al., "A Tc-99m Labelled Monoclonal Antibody,PR1A3, for Radioimmunoschintigraphy, RIS, of Colorectal Cancer," J. Nucl. Med., vol. 30, p. 748 (No. 80) (1989).
Greaves, et al., "Lymphocyte Activation--Binding Sites for Phytomitogens on Lyphycyte Subpopulations," Clin. Exp. Immunol., vol. 10, pp. 537-554 (1972).
Hnatowich, et al., "Antibody Radiolabeling, Problems and Promises," Nucl. Med. Biol., vol. 17, No. 1 pp. 49-55 (1990).
Hnatowich, et al., "Recent Developments in the Radiolabeling of Antibodies with Iodine, Indium, and Technetium," Sem. in Nucl. Med., vol. XX, No. 1, pp. 80-91 (Jan. 1990).
Hoffman, et al., "Synthesis of Mitogenic Phytohemagglutinin-L in Escherichia coli,"Bio/Tech., vol. 5, pp. 157-160 (Feb. 1987).
Houston, et al., "Specific In Vivo Localization of Monoclonal Antibodies Directed Against the Thy 1.1 Antigen," J. Immun., vol. 125, No. 2, pp. 837-843 (1980).
Hynes "Integrins: A Family of Cell Surface Receptors," Review, Cell, vol. 48, pp. 549-554 (1987).
Iverson, et al., "Metalloantibodies," Reports, Science, vol. 249, pp. 659-662 (Aug. 1990).
Janeczek, et al., "Autoradiographic Analysis of Formylpeptide Chemoattractant Binding, Uptake and Intracellular Processing of Neutrophils," J. Cell Sci 94, pp. 155-168 (1989).
Jaziri, et al., "Specific Binding Sites on Human Phagocytic Blood Cells for Gly-Leu-Phe and Val-Glu-Pro-Ile-Pro-Tyr, Immunostimulating Peptides from Human Milk Proteins," BioChimica et Biophysica Acta, vol. 1160, pp. 251-261 (1992).
Khaw, et al., "Technetium-99m Labeling of Antibodies to Cardiac Myosin Fab and to Human Fibrinogen," J. Nucl. Med, vol. 23, No. 11, pp. 1011-1019 (1982).
Krejcarek, et al., "Covalent Attachment of Chelating Groups to Macromolecules," Biochm. and Biophys. Res. Comm., vol. 77, No. 2, pp. 581-585 (1977).
Kwekkeboom, et al., "Octrolotide Scintigraphy in Neuro-Endocrine Tumors," J. Nucl. Med, vol. 32, No. 5, p. 981 (May 1991) Abstract.
Kwekkeboom, et al., "Radioiodinated Somatostatin Analog Schintigrahy in Small-Cell Lung Cancer," J. Nucl. Med., vol. 32, No. 10, pp. 1845-1848 (Oct. 1991).
Lavender, et al., "Kinetics of Indium-III Labelled Lymphocytes in Normal Subjects and Patients with Hodgkin's Disease," British Med. Jour., vol. 2, pp. 797-799 (Sep. 1977).
Lever, et al., "Synthesis of a Novel Bifunctional Chelate Designed for Labeling Proteins with Technetium-99m," Tetrahedron Letters

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Leukostimulatory agent for in vivo leukocyte tagging does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Leukostimulatory agent for in vivo leukocyte tagging, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leukostimulatory agent for in vivo leukocyte tagging will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-594554

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.