Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1986-09-11
1989-07-18
Schain, Howard E.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530350, 530827, 435 68, 514 2, 514 8, 514 21, 424 851, C07K 1500, A61K 3700
Patent
active
048495069
ABSTRACT:
Leukoregulin is identified, a biologically active lymphokine of molecular weight of about 120,000 to 140,000, with subunits of about 30,000 to 35,000, having the isoelectric focusing pH's of between 4.8 and 5.5 or between 7.5 and 8.3, which has the ability to regulate tumor cell physiology and growth without affecting the growth of normal cells. Methods for stimulating its production by monouclear cells, methods for its isolation and purification, and methods for its therapeutic uses are also disclosed.
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Haspel Martin V.
McCabe Richard P.
Pomato Nicholas
Ransom Janet H.
Akzo N.V.
Blackstone Wiliam M.
Draper Garnette D.
Schain Howard E.
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