Leukoregulin, an antitumor lymphokine, and its therapeutic uses

Details Leukoregulin, an antitumor lymphokine, and its therapeutic uses Leukoregulin, an antitumor lymphokine, and its therapeutic uses

1989-05-11

1992-01-21

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

530351, 514 2, 514 8, 514 21, 435 695, A61K 3700, C07K 1500

Patent

active

050826573

ABSTRACT:
Leukoregulin is identified, a biologically active lymphokine of molecular weight of about 120,000 to 140,000 with subunits of about 30,000 to 35,000, having the isoelectric focusing pH's of between 4.8 and 5.5 or between 7.5 and 8.3, which has the ability to regulate tumor cell physiology and growth without affecting the growth of normal cells. Methods for stimulating its production by mononuclear cells, method for its isolation and purification, and methods for its therapeutic uses are also disclosed.

REFERENCES:
patent: 4849506 (1989-07-01), Ransom et al.
Evans et al. (1983) Cell. Immunol. 76, 295-303.
Ransom et al. (1988) in "Leukolysins and Cancer", (Ransom and Ortaldo, Eds), The Humana Press, Inc., Clifton, N.J., 313-317.

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