Leukorecruitin

Details Leukorecruitin Leukorecruitin

1981-09-10

1984-06-05

Bleutge, John C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112R, 435 68, 435 69, 424101, 424177, C07G 700

Patent

active

044527357

ABSTRACT:
The invention relates to SERUM-DERIVED "LEUKORECRUITIN", which is A PROTEIN MEDIATOR OF INFLAMMATION FROM MAMMALIAN SERUM specifically inducing positive leukocytosis reaction and leukocyte recruitment from the bone marrow into the blood of animals and humans without biological side-reactions. The process for the production and isolation of leukorecruitin is characterized in that mammalian serum is subjected to regulated and limited proteolysis by contact activation, the protein is then separated from other foreign constituents and proteins of serum in the form of a crude serum protein concentrate fraction, and/or the protein is separated from other serum-proteins by chromatography on hydroxyapatite. Leukorecruitin has very valuable pharmacological effects and can be used in compositions for specifically influencing the defense state of the animal or human body and for diagnostic purposes in hematological disorders.

REFERENCES:
Van Waarde, D., Blood, vol. 50, pp. 727-742, 1977.
Gordon, A., Annals New York Acad. Sci., 113, pp. 766-789, 1964.
Rother, K., Eur. J. Immunol., vol. 2, pp. 550-558, 1972.
Gerard, C., J. Biol. Chem., vol. 254, (Jul.), pp. 6346-6351, 1979.
Conroy, M., J. Immunol., vol. 116, pp. 1682-1687, 1976.
Wissler, J., Eurp. J. Immunol., vol. 2, pp. 73-96, 1972.
Ghebrehiwet, B., J. of Immunol., vol. 123, pp. 616-621, 1979.

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