Chemistry: analytical and immunological testing – Involving diffusion or migration of antigen or antibody
Patent
1981-06-09
1984-03-13
Marantz, Sidney
Chemistry: analytical and immunological testing
Involving diffusion or migration of antigen or antibody
436 63, 436 64, 436515, 436519, 436529, 436808, 436811, 436813, G01N 3348, G01N 3350, G01N 3354
Patent
active
044368240
ABSTRACT:
The method assesses the level of general and specific cellular immunocompetence by measuring the responses of individuals to antigens in vitro employing the phenomenon of Leukocyte Migration Inhibition (LMI). The present invention differs from the previously described LMI technique in that antigens are individually incorporated into the agarose of assay plates, requiring no preincubation of antigens with patient blood cell (leukocyte) suspensions. The LMI assay method described herein is a practical alternative to delayed hypersensitivity skin testing to identify cellular immune deficiency and avoids the risk and inconvenience of the skin test procedure. The method also allows in vitro diagnosis of Tuberculosis and monitoring of tumor therapy.
REFERENCES:
patent: 2304817 (1942-12-01), Grozin
patent: 3941876 (1976-03-01), Marinkovich
patent: 3960490 (1976-06-01), Giaever
patent: 3969497 (1976-07-01), Kniker
patent: 4081241 (1978-03-01), Porzsott
patent: 4157895 (1979-06-01), Finlay
patent: 4254219 (1981-03-01), Fullerton
patent: 4331650 (1982-05-01), Brewer
Chemical Abstracts, 87:51441y (1977).
Chemical Abstracts, 88:35693x (1978).
J. E. Clausen, Acta Allergologica, 30, 239-249 (1975).
J. E. Clausen, Acta Allergologica, 31, 116-129 (1976).
Manual of Clinical Immunology, N. R. Rose and H. Friedman, et al., American Society of Microbiology, 1976, Chapter 6-L. E. Spitler.
F. K. Nkrumah, et al., Int. J. Cancer: 20, 6-11 (1977) and D. H. Char, et al., N.E.J. Med: 291 (6), 274-277 (1974).
Clausen (Danish Med. Bull. 22(5):181-194; Acta Allergol. 28:145-158, 1973).
Dellenbaugh Geoffrey G.
Hofer Mark A.
Marantz Sidney
Ortho Diagnostic Systems Inc.
LandOfFree
Leukocyte migration through antigen containing agaroses for immu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Leukocyte migration through antigen containing agaroses for immu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leukocyte migration through antigen containing agaroses for immu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-492286