Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides

Details Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides

1997-10-03

2000-10-31

Mertz, Prema

Drug, bio-affecting and body treating compositions

Lymphokine

435 695, 435 711, 435 712, 4352523, 4353201, 435325, 435471, 530351, 930140, 536 235, A61K 3819, C07K 1452, C12N 1519

Patent

active

061398322

ABSTRACT:
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine .alpha.1(CK.alpha.1 or ck.alpha.-1), as well as Ck beta-11 and/or LAI-1 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

REFERENCES:
patent: 4897348 (1990-01-01), Johnson et al.
patent: 5278287 (1994-01-01), Rollins et al.
patent: 5306709 (1994-04-01), Gewirtz
patent: 5346686 (1994-09-01), Lyle et al.
patent: 5605817 (1997-02-01), Coleman et al.
patent: 5633149 (1997-05-01), Guegler et al.
Bowie et al, Science vol. 247, pp. 1306-1310, 1990.
George et al. Macromolecular Sequencing & Synthesis, vol. 12, pp. 127-149, Alan R. Liss, Inc. New York, 1988.
Colditz, I., et al., "In Vivo Inflammatory Activity of Neutrophil-Activating Factor, a Novel Chemotactic Peptide Derived from Human Monocytes," Am. J. Pathology 134:755-760 (1989).
Bischoff, S.C. et al., "Monocyte Chemotactic Protein 1 is a Potent Activator of Human Basophils," J. Exp. Med. 175:1271-1275 (May 1992).
Blum, S. et al., "Three Human Homologs of a Murine Gene Encoding an Inhibitor of Stem Cell Proliferation," DNA and Cell Biol. 9(8):589-602 (1990).
Brown, K.D. et al., "A Family of Small Inducible Proteins Secreted by Leukocytes Are members of a New Superfamily that Includes Leukocyte and Fibroblast-Derived Inflammatory Agents, Growth Factors, and Indicators of Various Activation Processes," J. Immunol. 142(2):679-687 (Jan. 1989).
Cunningham, B.C. and J.A. Wells, "High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis," Science 244:1080-1085 (1989).
Derynck, R. et al., "Recombinant Expression, Biochemical Characterization, and Biological Activities of the Human MGSA/gro Protein," Biochem. 29:10225-10233 (1990).
Goodman, R.B. et al., "Molecular Cloning of Porcine Alveolar Macrophage-Derived Neutrophil Chemotactic Factors I and II: Identification of Porcine Il-8 and Another Intercrine-.alpha. Protein," Biochem. 31(43):10483-10490 (1992).
Harlow, E. and D. Lane, Antibodies: a laboratory manual, Cold Spring Spring harbor Laboratory, Cold Spring Harbor, NY; p. 76 (1988).
Jose, P.J. et al., "Ectaxin: A Potent Eosinophil Chemoattractant Cytokine Detected in a Guinea Pig Model of Allergic Airways Inflammation," J. Exp. Med. 179:881-887 (Mar. 1994).
Kuna, P. et al., "Moncyte Chemotactic and Activating Factor is a Potent Histamine-releasing Factor for Human Basophils," J. Exp. Med. 175:489-493 (Feb. 1992).
Kurdowska, A. et al., "Biological and Kinetic Characterization of Recombinant Human Macrophage Inflammatory Peptides 2 Alpha and Beta and Comparison With the Neutrophil Activating Peptide 2 and Interleukin 8," Cytokine 6(2):124-134 (Mar. 1994).
Kwon, B.S. and S.M. Weissman, "cDNA sequences of two inducible T-cell genes," Proc. Natl. Acad. Sci. USA 86:1963-1967 (Mar. 1989).
Lukacs, N.W. et al., "The Role of Macrophage Inflammatory Protein 1.alpha. in Schistosoma mansoni Egg-induced Granulomatous Inflammation," J. Exp. Med. 177:1551-1559 (Jun. 1993).
Matsushima, K. et al., "Purification and Characterization of a Novel Monocyte Chemotactic and Activating Factor Produced By a Human Myelomonocytic Cell Line," J. Exp. Med. 169:1485-1490 (Apr. 1989).
Nakao, M. et al., "Structures of Human Genes Coding for Cytokine LD78 and Their Expression," Mol. Cell. Biol. 10(7):3646-3658 (Jul. 1990).
Obaru, K. et al., "A cDNA Clone Used to Study mRNA Inducible in Human Tonsillar Lymphocytes by a Tumor Promoter," J. Biochem. 99:885-894 (1986).
Schall, T.J., "Biology of the Rantes/Sis Cytokine Family," Cytokine 3(3):165-183 (May 1991).
Sudo, K. et al., "2058 Expressed Sequence Tags (ESTs) from a Human Fetal Lung cDNA Library," Genomics 24:276-279 (Dec. 1994).
Zipfel, P.F. et al., "Mitogenic Activation of Human T Cells Induces Two Closely Related Genes Which Share Structural Similarities With a New Family of Secreted Factors," J. Imunol. 142(5):1582-1590 (Mar. 1989).
English Language Abstract of EP 0 488 900 (Document AM1), WPI Acc No: 92-185765/23.
International Search Report for Appl. No. PCT/US 97/17716, mailed Feb. 1998 .

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