Leukemic cell-adsorbing material containing lectin protein...

Details Leukemic cell-adsorbing material containing lectin protein... Leukemic cell-adsorbing material containing lectin protein...

2006-01-17

2006-01-17

Naff, David M. (Department: 1651)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S177000, C435S178000, C435S261000, C530S396000, C530S402000, C530S413000, C530S812000, C530S813000

Reexamination Certificate

active

06987022

ABSTRACT:
An efficient method for therapeutic treatment of a leukemic patient is disclosed in which the patient's body fluid under external circulation is brought into direct contact with an adsorbent material capable of adsorbing the leukemic cells in the body fluid specifically and selectively. The leukemic cell-adsorbent material, which is used by filling a column to form an adsorbent bed, is a conjugate of a lectin protein extracted from, e.g.,Dolichosbeans or soybeans coupled with a physiologically inert carrier material such as a polysaccharide in the form of beads or a superparamagnetic material in the form of iron oxide-based magnetic beads.

REFERENCES:
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patent: 5081030 (1992-01-01), Civin
patent: 6420171 (2002-07-01), Nakamura et al.
patent: 9-206096 (1997-08-01), None
Hellstrom et al, The Juornal of Experimental Medicine, 1976, vol. 144, pp. 1381-1385.

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