Leukemia inhibitory factor from mammalian species and use thereo

Details Leukemia inhibitory factor from mammalian species and use thereo Leukemia inhibitory factor from mammalian species and use thereo

1996-08-21

1999-10-05

Crouch, Deborah

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435325, 435353, 435354, 435366, 435377, 435378, 600 33, 800 8, C12N 500, C12N 1500, A61B 143

Patent

active

059623217

ABSTRACT:
Leukemia inhibitory factor or LIF as an addition to culture media promotes the development of embryos to the implantation stage. Growth in the presence of LIF increases the percentage of embryos that reach the implantation stage than growth without LIF. LIF is isolatable from several mammalian species such as murine, sheep, pig, cow, horse or donkey.

REFERENCES:
patent: 5366888 (1994-11-01), Fry et al.
Gearing et al (1987) EMBO J 6, 3995-4002.
Gearing et al. (1987) "Molecular Cloning and Expression of cDNA Encoding a Murine Myeloid Leukaemia Inhibitory Factor (LIF)", EMBO J. 6:3995-4002.
Smith, et al. (1988) "Inhibition of Pluripotential Embryonic Stem Cell Differentiation by Purified Polypeptides", Nature 336:688-690.
Williams, et al. (1988) "Myeloid Leukaemia Inhibitory Factor Maintains the Developmental Potential of Embryonic Stem Cells", Nature 336:684-687.
Robertson, et al. (1990) "In Vitro Models of the Maternal-Fetal Interface" in Molecular and Cellular Immunology of the Maternal-Fetal Interface, Wegmann, et al., eds., Oxford University Press, NY:191-206.

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