Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1998-10-15
2000-12-05
Moezie, F. T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514886, 514887, 424 851, 424 852, 424 854, A61K 3816, A61K 3800
Patent
active
061567299
ABSTRACT:
A method for inhibiting and/or reducing inflammation and/or pain in an individual is provided. The method comprises administration of leukemia inhibitory factor (LIF) to a cell or an individual in an amount effective to inhibit and/or reduce inflammation and/or pain.
REFERENCES:
patent: 5344644 (1994-09-01), Igari et al.
patent: 5416071 (1995-05-01), Igari et al.
patent: 5639275 (1997-06-01), Baetge et al.
Patterson, "Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology," Proc Natl Acad Sci USA, 91:7833-7835 (Aug. 1994).
Alexander et al., "D-Factor/Leukaemia Inhibitory Factor: Evidence for its Role as a Mediator in Acute and Chronic Inflammatory Disease," Cytokine, 6(6):589-586 (Nov. 1994).
Brown et al., "Leukaemeia Inhibitory Factor and Interleukin 6 are Expressed at Very Low Levels in the Normal Adult Mouse and Are Induced by Inflammation," Cytokine, 6(3):300-309 (May 19994).
Ulich et al., "Intratracheal injection of LPS and cytokines. V. LPS induces expression of LIF and LIF inhibits acute inflammation," Amer J. Physiol., L443-L 446 (1994).
Heyman et al., "Leukaemia Inhibitory Factor (LIF) Production in Pleural Effusions: Comparison with production of IL-4, IL-8, IL-10 and Macrophage-Colony Stimulating Factor (M-CSF)," Cytokine, 5(5):410-416 (May 1996).
Kurek et al., "UP-Regulation of Leukaemia Inhibitory Factor and Interleukin-6 in Transected Sciatic Nerve and Muscle Following Denervation," Neuromusc Disorders, 6(2):105-114 (1996).
Banner et al., "Leukemia Inhibitory Factor is Expressed in Astrocytes Following Cortical Brain Injury," Exper Neurol, 147:1-9 (1997).
Rao et al., "Leukemia Inhibitory Factor Mediates an Injury Response but Not a Target-Directed Developmental Transmitter Switch in Sympathetic Neurons," Neuron, 11:1175-1185 (Dec. 1993).
Corness et al., "Influence of leukemia inhibitory factor on galanin/GMAP and neuropeptide Y expression in mouse primary sensory neurons after axotomy," Exp Brain Res, 112:79-88 (1996).
Tham et al., "Leukemia Inhibitory Factor Enhances the Regeneration of Transected Rat Sciatic Nerve and the Function of Reinnervated Muscle," J Neurosci Res, 47:208-215 (1997).
Banner et al., "Leukemia Inhibitory Factor Is an Anti-Flammatory and Analgesic Cytokine," J. Neurosci., 18(14):5456-5462 (Jul. 15, 1998).
Patterson Paul H.
Woolf Clifford J.
California Institute of Technology
Moezie F. T.
Trecartin Richard F.
Vance Dolly A.
LandOfFree
Leukemia inhibitory factor for use in modulating inflammation an does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Leukemia inhibitory factor for use in modulating inflammation an, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leukemia inhibitory factor for use in modulating inflammation an will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-961802