Leukaemia inhibitory factor

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 695, 4352402, 4352523, 43525233, 435255, 4353201, 536 235, 536 2351, 536 241, 536 2431, C12P 2106, C12N 500, C07H 1512

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051870770

ABSTRACT:
A leukaemia-inhibitory factor (LIF) is disclosed, together with a method of preparation of LIF in essentially pure form. Nucleotide and amino acid sequences are disclosed, together with recombinant DNA moleclues and host cells for production of polypeptides having LIF activity.

REFERENCES:
Gearing et al. "Cloning, Sequencing, and Expression of Murine and Human Leukemia Inhibitory Factor (LIF)-encoding DNA" CA 110 187328 t (1988).
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Grantham, et al., Nucleic Acids Res., 9:r43-r74 (1981).
Kelso, et al., Exp. Hematol., 13:7-15 (1985).
Gough, J. Mol. Biol., 165:683-699 (1983).
Gearing, et al., Embo J., 6:3995-4002 (1987).
Smith and Johnson, Gene, 67:31-40 (1988).
Baumann, H., Hill, R. E., Sauder, D. N. and Jahreis, G. P. (1986), J. Cell Biol. 102(2) pp. 370-383.
Japanese Patent Specification No. Hei 1-148197 (Green Cross Co.)-Published Jun. 9, 1989.

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