Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1995-03-29
1998-05-12
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530395, 530413, 530416, 530417, 435 695, 435 712, 4352523, 4353201, C07K 1452, C07K 116
Patent
active
057506540
ABSTRACT:
The present invention provides isolated DNA molecules encoding human and murine LIF, and methods of producing LIF by the expression of the isolated DNA in suitable host cells. The invention further provides human and murine LIF polypeptides, pharmaceutical compositions containing LIF, and methods of use thereof.
REFERENCES:
patent: 4760021 (1988-07-01), Mimura et al.
patent: 5104650 (1992-04-01), Ralph et al.
patent: 5187077 (1993-02-01), Gearing et al.
patent: 5427925 (1995-06-01), Gearing et al.
patent: 5443825 (1995-08-01), Gearing et al.
Williams et al "Myeloid Leukaemia Inhibitory Factor . . . " Nature 336: 684-687 (Dec. 1988).
Yamamori et al "The Cholinergic Neuronal Differentiation Factor . . . " Science 246: 1412-1416 (Dec. 1989).
Fukada, "Purification and Partial Characterization . . . " PNAS 82: 8795-8799 (Dec. 1985).
Boyer, Modern Experimental Biochemistry, pp. 96-117, Addison Wesley Publ. Co (1986).
Moreau et al "Capacity of Alloreactive Human T Clones . . . " Ann. Inst. Pasteur/Immunol. 137 C:25-37 (Jan./Feb. 1986).
Moreau et al, "Leukaemia Inhibitory Factor is Identical to . . . " Nature 336:690-692 (Dec. 1988).
Moreau et al "Characterization of a Factor . . . " J. Immunol. 138(11): 3844-3849 (Jun. 1987).
Koopman et al "A Factor Produced by Feeder Cells . . . " Exp. Cell Res. 154: 233-242 (1984).
Tomida et al "Purification of a Factor Inducing Differentiation . . . " J. Biol. Chem. 259(17): 10978-10982 (Sep. 1984).
Tomida et al "Characterization of a Factor Inducing Differentiation . . . " FEBS Lett. 178(2): 292-296 (Dec. 1984).
Shabo et al "The Myeloid Blood Cell Differentiation-Inducing Protein . . . " Blood 72(6): 2070-2073 (Dec. 1988).
Lowe et al "Genomic Cloning and Heterologous Expression . . . " DNA 8(5): 351-359 (1989).
Abe et al (1986) "Differentiation-inducing factor purified from conditioned medium of mitogen treated spleen cell cultures stimulates bone resorption," Proc. Natl. Acad. Sci. USA, 83:5958-5962.
Baumann et al (1986) "Regulation of Major Acute-phase Plasma Proteins by Hepatocyte-stimulating Factors of Human Squamous Carcinoma Cells," J. Cell Biol. 102: 370-383.
Fukada (1980) "Hormonal control of neurotransmitter choice in sympathetic neurone cultures," Nature 287: 553-555.
Fukada (1985) "Purification and partial characterization of a cholinergic neuronal differentiation factor," Proc. Natl. Acad. Sci. USA 82:8795-8799.
Kelso, et al (1985) "Characteristics of Colony-stimulating Factor Production by Murine T-lymphocyte Clones," Exp. Hematology 13:7-15.
Kelso, et al (1986) "Independent Regulation of Granulocyte-Macrophage Colony-Stimulating Factor and Multi-Lineage Colony-Stimulating Factor Production in T Lymphocyte Clones," J. Immunol. 136:1718-1725.
Koopman, et al (1984) "A Factor Produced by Feeder Cells Which Inhibits Embryonal Carcinoma Cell Differentiation," Exp. Cell Res. 154:233-242.
Lipton, et al (1981) "Characterization of Macrophase- and Granulocyte-Inducing Proteins for Normal and Leukemic Myeloid Cells Produced by the Krebs Ascites Tumor," Biochem. Biophys. Acta 673:552-569.
Moreau, et al (1987) "Characterization of a Factor Produced by Human T Cell Clones Exhibiting Eosinophil-Activating and Burst -Promoting Activities," J. Immunol. 138:3844-3849.
Moreau, et al (1986) "Capacity of alloreactive human T clones to produce factor(s) inducing proliferation of the interleukin-3-dependent DA-1 murine cell line: I. Evidence that this production is under interleukin 2 control," Biol. Abst. 81:AB-489 Ref. No. 112012.
Moreau, et al (1986) "Capacity of Alloreactive Human T Clones to Produce Factor(s) Inducing Proliferation of the IL3-Dependent DA-1 Murine Cell Line," Ann. Inst. Pasteur/Immunol. 137C:25-37.
Nicola, et al (1986) "Binding of Iodinated Multipotential Colony-Stimulating Factor (Interleukin-3) to Murine Bone Marrow Cells," J. Cell Physiol. 128:180-188.
Nicola, et al (1983) "Purification of a Factor Inducing Differentiation in Murine Myelomonocytic Leukemia Cells," J. Biol. Chem. 258:9017-9023.
Sachs (1982) "Control of Growth and Normal Differentiation in Leukemic Cells: Regulation of the Development Program and Restoration of the Normal Phenotype in Myeloid Leukemia," J. Cell. Physiol. Supp. 1:151-164.
Takeda et al (1986) "Identity of differentiation inducing factor and tumour necrosis factor," Nature 323:338-340.
Tomida, et al (1984) "Characterization of a factor inducing differentiation of mouse myeloid leukemic cells purified from conditioned medium of mouse Ehrlich ascites tumor cells," FEBS Letters 178:291-296.
Tomida et al (1984) "Purification of a Factor Inducing Differentiation of Mouse Myeloid Leukemic M1 Cells from Conditioned Medium of Mouse Fibroblast L929 Cells," J. Biol. Chem. 259:10978-10982.
Weber (1981) "A Diffusible Factor Responsible for the Determination of Cholingergic Functions in Cultured Sympathetic Neurons," J. Biol. Chem. 256:3447-3453.
Gearing David Paul
Gough Nicholas Martin
Hilton Douglas James
King Julie Ann
Metcalf Donald
Amrad Corporation Limited
Mertz Prema
Ulm John
LandOfFree
Leukaemia inhibitory factor does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Leukaemia inhibitory factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leukaemia inhibitory factor will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-980061