Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for...
Patent
1997-04-18
1999-02-02
Wax, Robert A.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
435 6, 4353201, 4352523, 43525411, 435325, 536 232, 536 234, C12N 900, C12N 120, C12N 1500, C07H 2104
Patent
active
058663908
ABSTRACT:
The invention provides leuS polypeptides and DNA (RNA) encoding leuS polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing leuS polypeptides to screen for antibacterial compounds.
REFERENCES:
R. Calander et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis", Biochemistry, 5(5), pp. 1681-1690 (1966).
J. Hughes et al., "How does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) pp. 322-324 (1980).
Fraser et al., "The minimal gene complement of Mycoplasma genitalium," Science, 270 pp. 397-403 (1995).
Dissertation Abstracts International, vol. 45, No. 6N, 1984 p. 1673, DANA, S.L.S. "Genetic mapping and molecular cloning of specific genes using interspecific human-chinese hamster cell hybrids (chromosome-5, leucyl transfer-RNA synthetase)".
Dissertation Abstracts International, vol. 45, No. 3B, 1983 p. 772, Chang S.M.W. Genetic and biochemical studies of aminoacyl-transfer-RNA synthetase mutants and their revertants in chinese hamster lung cells.
Vinella et al., "Penicillin-binding protein 2 inactivation in Escherchia coli results in cell deivision inhibition, which is relieved by FtsZ overexpression," J. of Bacteriology, 175(20) pp. 6704-6710 (1993).
Hartlein et al., "Molecular cloning and nucleotide sequence of the gene for Escherichia voli leucyl-tRNA synthetase," Nucleic Acids Research, 15(4), pp. 10199-10210 (1987).
Fleischmann et al. (1995) Whole-Genome Random Sequencing and Assembly of Haemophilus influenza Rd. Science 269: 496-512.
Vander Horn et al. (1992) Cloning and Nucleotide Sequence of the Leucyl-tRNA Synthetase Gene of Bacillus subtilis. J. Bacteriol. 174(12): 3928-3935.
Gimmi Edward R.
Hobbs Lisa J.
King William T.
SmithKline Beecham Corporation
SmithKline Beecham p.l.c.
LandOfFree
Leucyl tRNA synthetase polynucleotides of streptococcus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Leucyl tRNA synthetase polynucleotides of streptococcus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leucyl tRNA synthetase polynucleotides of streptococcus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1116503