Leucyl tRNA synthetase from staphylococcus aureus

Details Leucyl tRNA synthetase from staphylococcus aureus Leucyl tRNA synthetase from staphylococcus aureus

1997-12-23

1999-11-30

Hobbs, Lisa

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 435440, 5303871, C12N 900, C12N 1500, C12Q 168, C07K 1600

Patent

active

059941111

ABSTRACT:
The invention provides novel tRNA synthetase polypeptides and DNA (RNA) encoding tRNA synthetase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tRNA synthetase polypeptide for the protection against infection, particularly bacterial infections.

REFERENCES:
patent: 5561054 (1996-10-01), Kron et al.
Vander Horn et al. (1992) Cloning and Nucleotide Sequence of the Leucyl-tRNA Synthetase Gene of Bacillus subtilis. J. Bacteriol. 174(12): 3928-3935.
Kron, et al., "An immunodominant antigen of Brugia malayi is an asparaginyl-tRNA synthetase", FEBS Letters, 374 pp. 122-124 (1995).
Chalker, et al., "Analysis and toxic overexpression in Escherichia coli of a staphylococcal gene encoding isoleucyl-tRNA synthetase", Gene, 141, pp. 103-108 (1994).
Nilsen, et al., "Cloning and characterization of a potentially protective antigen in lymphatic filariasis", Proc. Natl. Acad. Sci. USA, 85, pp. 3604-3607 (1988).
Bork, et al., "Exploring the Mycoplasma capricolum genome: a minimal cell reveals its physiology", Molecular Microbiology, 16(5), pp. 955-967 (1986).
Kazura, et al., "Differential Recognition of a Protective Filarial Antigen by Antibodies from Humans with Bancroftian Filariasis", J. Clin. Invest., 77, pp. 1985-1992 (1986).
Vander Horn, et al., "Cloning and nucleic acid sequence of the leucyl-tRNA-synthetase gene of Bacillus subtilis", Database EMBL, AC M88581, (1992).

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