Leucotriene antagonists

Details Leucotriene antagonists Leucotriene antagonists

1982-08-25

1984-05-15

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465E, 560 43, 562452, 562455, 564167, 564443, 424304, 424309, 424319, 424324, 424330, C07C12180, C07C 69612, C07C10329

Patent

active

044487290

ABSTRACT:
The compounds ##STR1## wherein each X is, independently, --O-- or --NR.sub.5, in which R.sub.5 is hydrogen or alkyl; R is alkyl, R.sub.1 is hydrogen or alkyl, R.sub.2 is hydrogen, hydroxy, amino, alkylamino, dialkylamino or alkanoylamino and when m or n is O, R.sub.2 is hydroxymethyl, aminomethyl, alkylaminomethyl, dialkylaminomethyl or alkanoylaminomethyl; R.sub.3 is hydrogen, --CN, --CONH.sub.2 or --CO.sub.2 M in which M is hydrogen, alkyl or ##STR2## in which p is an integer from 2 to 6 and R.sub.6 and R.sub.7 are, independently, hydrogen or alkyl; R.sub.4 is --NH.sub.2, --NHCOR.sub.8 in which R.sub.8 is alkyl, --NHCOCO.sub.2 Z or --NHCOCH.sub.2 CH.sub.2 CO.sub.2 Z in which Z is hydrogen or alkyl; m and n are 0, 1, 2, 3 or 4 such that when n is from 1 to 4, m is 0 or 1 and when m is from 1 to 4, n is 0 or 1; or pharmaceutically acceptable salts thereof are leucotriene antagonists useful as antiallergy agents.

REFERENCES:
patent: 4296120 (1981-10-01), Kadin
patent: 4296129 (1981-10-01), Kadin
patent: 4296237 (1981-10-01), Cragoe
Appleton et al., J. Med. Chem., 20, 371-379 (1977).
Buckle et al., J. Med. Chem., 22, 158-168 (1979).
Samuelsson, TIPS Reviews, pp. 227-230, May 1980.
Marx, Science, 215, 1380-1383 (1982).

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