Leu3a binding peptides

Details Leu3a binding peptides Leu3a binding peptides

1990-05-22

1992-12-15

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530324, C07K 708, A61K 3702

Patent

active

051718383

ABSTRACT:
Compositions comprising peptide analogues of a CD4 epitope capable of interacting with a monoclonal antibody designated Leu3a or with the envelope glycoprotein (gp120) of the human immunodeficiency virus (HIV) are provided. In a preferred embodiment, the peptide will consist of the amino acid sequence: ser-lys-leu-asn-asp-arg-ala-asp-ser-arg-arg-ser-leu-trp-asp. The invention also includes a series of peptides having one or more D-amino acid substitution that confer enhanced resistance to degradation in serum. Pharmaceutical compositions and methods for using the peptides in therapeutic applications are also provided.

REFERENCES:
Classon et al., Proc. Natl. Acad. Sci. U.S.A. 83: 4499-4503 (1986).
Sattentau et al., Science 23: 1120-1123 (1986).
Dalgleish et al., The Lancet, Nov. 7, 1987, pp. 1047-1050.
Landau et al., Nature 334: 159-162 (1988).
Jameson et al., Science 240: 1335-1339 (1988).
Peterson and Seed, Cell 54: 65-72 (1988).
Hayashi et al., Arch. Virol. 105: 129-135 (1989).
Maddon et al., Cell, vol. 42, 1985, pp. 93-104.

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