Letrozole purification process

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S262200

Reexamination Certificate

active

07465749

ABSTRACT:
Provided is a process for purifying a letrozole product that contains an isoletrozole impurity, which process preferably includes converting at least a portion of the isoletrozole impurity into 4,4′-dicyanobenzophenone and removing 4,4′-dicyanobenzophenone, to produce a purified letrozole product.

REFERENCES:
patent: 4978672 (1990-12-01), Bowman et al.
patent: 5073574 (1991-12-01), Lang
patent: 5378721 (1995-01-01), Lang
patent: 5473078 (1995-12-01), Bowman et al.
patent: 2006/0128775 (2006-06-01), Patel et al.
patent: 1754876 (2006-04-01), None
patent: WO 2004/076409 (2004-09-01), None
patent: WO 2005/047269 (2005-05-01), None

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