LETM1: modulators of cellular proliferation

Details LETM1: modulators of cellular proliferation LETM1: modulators of cellular proliferation

2006-02-28

2006-02-28

Nickol, Gary B. (Department: 1642)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

C435S006120, C435S007100

Reexamination Certificate

active

07005254

ABSTRACT:
The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding LETM1 (“leucine zipper EF hand transmembrane receptor”), which is involved in modulation of cellular proliferation and cell cycle regulation. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, siRNA, antisense nucleic acids, and ribozymes, that modulate cell cycle regulation and cellular proliferation via modulation of LETM1 and LETM1 related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation.

REFERENCES:
patent: 2002/0132753 (2002-09-01), Rosen et al.
Endele, et al.; “LETM1, A Novel Gene Encoding a Putative EF-Hand Ca2+-Binding Protein, Flanks the Wolf-Hirschhorn Syndrome (WHS) Critical Region and Is Deleted in Most WHS Patents”, Genomics 60, 218-225 (1999).
Database GenBank, Accession No. AF061025, Oct. 5, 1999.

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