Leptin-related peptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C530S329000

Reexamination Certificate

active

10458334

ABSTRACT:
The present invention relates to methods and compositions containing novel leptin peptides, preferably for the modulation of body mass (i.e., weight), more specifically for novel diagnostic and therapeutic applications in homeostasis of body weight and adipose tissue mass.

REFERENCES:
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patent: WO 98/18486 (1998-05-01), None
patent: WO 98/24896 (1998-06-01), None
Jequier and Tappy , Physiological Rev. 79: 451-480, 1999.
Grasso et al., “In vivo effects of Leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of Leptin activity to domains between amino acid residues 106-140” Endocrinology 138(4):1413-1418 (1997).
Martinez et al., “Role of fragment peptides from ob protein on body weight and thermogenesis control: a screening” Journal of Physiology and Biochemistry 52(2): 123-124 (1996).
Fruhbeck et al., “Age-related differences in the thermogenic and ponderal effects of fragment peptides from the rat ob protein.” Regulatory Peptides 73(2) 83-87 (1998).
Sampson et al., “A 35 amino acid fragment of leptin inhibits feeding in the rat” Endocrinology 137(11): 5182-5185 (1996).
Grasso et al., “Epitope mapping of secreted mouse Leptin utilizing peripherally administered synthetic peptides” Regulatory Peptides 85(23): 93-100 (1999).
Malendowics et al., “Leptin(116-130) enhances the proliferative activity of immature rat adrenal cortex.” Medical Science Research 27: 675-676 (1999).
Grasso et al., “Inhibitory Effects of Leptin-Related Synthetic Peptide 116-130 on Food Intake and Body Weight Gain in Female C57BL/6J ob/ob Mice May Not Be Mediated by Peptide Activation of the Long Isoform of the Leptin Receptor.” Diabetes 48:2204-2209 (1999).
Gonzalez et al., “Effect of acute immunoneutralization of endogenous leptin on prolactin an LH secretion during the afternoon of pro-oestrus or in steroid-treated ovariectomized female rats.” Journal of Reproduction and Fertility 118: 39-45 (2000).
Gonzalez et al., “Leptin 116-130 Stimulates Prolactin and Luteinizing Hormone Secretion in Fasted Adult Male Rats.” Neuroendocrinology 70:213-220 (1999).
Grasso et al. 1997 Eastern Great Lakes Endocrine Symposium. (Albany, NY) Poster Abstract. Nov. 3, 1997.
Grasso et al. 80thAnnual Meeting of the Endocrine Society. Poster Abstract. 1998.
Grasso et al. 81stAnnual Meeting of the Endocrine Society, San Diego CA. Post Abstract. Jun. 12-15, 1999.

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