Leptin peptide antagonists

Details Leptin peptide antagonists Leptin peptide antagonists

2004-05-07

2008-08-05

Landsman, Robert S. (Department: 1646)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C530S300000

Reexamination Certificate

active

07407929

ABSTRACT:
Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence.

REFERENCES:
patent: 6399745 (2002-06-01), Ertl et al.
patent: 2002/0160935 (2002-10-01), Cawthorne et al.
patent: 2004/0048773 (2004-03-01), Cawthorne et al.
patent: 2004/0229783 (2004-11-01), Pothoulakis et al.
Matuuoka et al., Biochem. Biophys. Res. Commun. 256: 480-484, 1999.
Verploegen et al., FEBS Letters 405, 237-240, 1997.
Rohner-Jearnrenaud et al., The New Eng. J. Med., 334: 324-325, 1996.
Campfield et al., Science 280: 1383-1387, 1998.
Grasso et al., Endocrinol. 138: 1413-1418, 1997.

Affiliated with

Also associated with

Rating

Leptin peptide antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Leptin peptide antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leptin peptide antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4007006