Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-11-06
2007-11-06
Landsman, Robert S. (Department: 1646)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S069100, C435S353000, C530S351000
Reexamination Certificate
active
10235264
ABSTRACT:
Methods of activating a signaling cascade comprising, introducing leptin and/or a cytokine to a receptor complex comprising gp 130, optionally in combination with a compound acting on adenylate cyclase or acting on one or more downstream targets of adenylate cyclase, thereby inducing genes in neuro-endocrine cells or cells of neuro-endocrine origin. Two distinct gene-sets are induced, immediate early response genes (STAT-3, SOCS-3, Metallothionein-II, the serine/threonine kinase Fnk and the rat homologue of MRF-1), and late induced target genes (Pancreatitis Associated Protein I, Squalene Epoxidase, Uridinediphosphate Glucuronyl Transferase and Annexin VIII). Strong co-stimulation with the adenylate cyclase activator forskolin was shown with respect to late induced target genes. Transcripts encoding Leptin Induced Protein I (LIP-I) and Leptin Induced Protein II (LIP-II) were identified; however, no forskolin co-stimulatory effect was observed. It is also demonstrated that leptin modulates in vivo expression of MT-II, Fnk and Pancreatitis Associated Protein I genes.
REFERENCES:
patent: 5521066 (1996-05-01), Menzel et al.
patent: 5686281 (1997-11-01), Roberts
patent: 5716622 (1998-02-01), Darnell et al.
patent: 5744314 (1998-04-01), Menzel et al.
patent: 5776689 (1998-07-01), Karin et al.
patent: 5843697 (1998-12-01), Pestka et al.
patent: 5885779 (1999-03-01), Sadowski et al.
patent: 5972621 (1999-10-01), Tartaglia et al.
patent: 6001816 (1999-12-01), Morsy et al.
patent: 6270964 (2001-08-01), Michnick et al.
patent: 6294330 (2001-09-01), Michnick et al.
patent: 6303319 (2001-10-01), Rickles
patent: 6342345 (2002-01-01), Blau et al.
patent: 6734006 (2004-05-01), Xiao et al.
patent: 2001/0023062 (2001-09-01), Ostade et al.
patent: 0 646 644 (1995-04-01), None
patent: 0832219 (1997-01-01), None
patent: 0912609 (1997-12-01), None
patent: WO 97/00319 (1997-01-01), None
patent: WO 97/20933 (1997-06-01), None
patent: WO 97/26335 (1997-07-01), None
patent: WO 97/31113 (1997-08-01), None
patent: WO 98/02542 (1998-01-01), None
patent: WO 98/12224 (1998-03-01), None
patent: WO 98/20158 (1998-05-01), None
patent: WO 98/34120 (1998-08-01), None
patent: WO 98/44350 (1998-10-01), None
patent: WO 99/03974 (1999-01-01), None
patent: WO 99/40946 (1999-08-01), None
patent: WO 00/06722 (2000-02-01), None
patent: WO 00/07014 (2000-02-01), None
patent: WO 00/07038 (2000-02-01), None
patent: WO 02/40543 (2002-05-01), None
patent: WO 02/062833 (2002-08-01), None
Baumann et al., Proc. Natl. Acad. Sci. USA 93: 8374-8378, 1996.
David et al., J. Biol. Chem. 271: 4585-4588, 1996.
Ghilardi et al., Proc. Natl. Acad. Sci. USA 93: 6231-6235, 1996.
Nakashima et al., FEBS, 403: 79/82, 1997.
Bjorbaek et al., Mol. Cell. 1: 619-625, 1998.
Ray et al., J. Clin. Invest. 97: 1852-1859, 1996.
Iyengar, R, FASEB J. 7: 768-775, 1993.
Beattie et al., “Obesity and Hyperleptinemia in Metallothionein (-I and -II) Null Mice”, Proceedings of the National Academy of Sciences of USA, vol. 95, Jan. 1998, pp. 358-363.
Bjorback et al., “Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance”, Molecular Cell, vol. 1, No. 4, Mar. 1998, pp. 619-625.
Vaisse et al., “Leptin Activation of Stat3 in the Hypothalamus of Wild-Type and ob/ob Mice but not db/db Mice”, Nature Genetics, vol. 14, Sep. 14, 1996, pp. 95-97.
Waelput et al., “Analysis of Signal Transduction via the Leptin Receptor”, International Journal of Obesity, vol. 22, No. Suppl. 3, Aug. 1998, p. S99.
PCT International Preliminary Examination Report, PCT/EP99/05489, dated Oct. 5, 2000.
PCT International Search Report, PCT/EP99/05489, dated Feb. 2, 2000, 6 pages.
PCT Written Opinion, PCT/EP99/05489, dated May 19, 2000, 8 pages.
Reply to Written Opinion for PCT/EP99/05489, letter dated Aug. 17, 2000, 6 pages.
Dusetti et al. Structural organization of the gene encoding the rat pancreatitis-associated protein vol. 268, Jul. 5, 1993, pp. 14470-14475.
Dusetti et al. The pancreatitis-associated protein I promoter allows targeting to the pancreas of a foreign gene whose expression is un-regulated during pancreatic inflammation pp. 5800-5804, Feb. 28, 1997.
Daly et al., Recognition of human colon cancer by T cells transduced with a chimeric receptor gene, Cancer Gene Therapy, 2000, pp. 284-291, vol. 7, No. 2.
Eyckerman et al., Design and application of a cytokine-receptor-based interaction trap, Nature Cell Biology, Dec. 2001, pp. 1114-1119, vol. 3, EBSCO Publishing.
Stoffel et al., Permissive role of thrombopoietin and granulocyte colony-stimulating factor receptors in hematopoietic cell fate decision in vivo, Proc. Natl. Acad. Sci., Jan. 1999, pp. 698-702, vol. 96.
Bjorbaek et al., The Role of SOCS-3 in Liptin Signaling and Leptin Resistance, The Journal of Biological Chemistry, Oct. 15, 1999, pp. 30059-30065, vol. 274, No. 42.
Bonnefoy-Berard et al., Vav: Function and Regulation in Hematopoietic Cell Signaling, Stem Cells, 1996, pp. 250-268, vol. 14.
Gisselbrecht, The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling, European Cytokine Network, Dec. 1999, pp. 463-470, vol. 10, No. 4.
Lee et al., Abnormal splicing of the leptin receptor in diabetic mice, Nature, Feb. 15, 1996, pp. 632-635, vol. 379.
Mercer et al., Localization of leptin receptor mRNA and the long form splice variant (OB-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization, FEBS Letters, 1996, pp. 113-116, vol. 387.
Tartaglia et al., Identification and Expression Cloning of a Leptin Receptor, OB-R, Cell, Dec. 29, 1995, pp. 1263-1271, vol. 83.
Zabeau et al., The ins and outs of leptin receptor activation, FEBS Letters, 2003, pp. 45-50, vol. 546.
Banks et al., Activation of Downstream Signals by the Long Form of the Leptin Receptor, Journal of Biological Chemistry, May 12, 2000, pp. 14563-14572, vol. 275, No. 19, U.S.A.
Campfield et al., Science, 1998, pp. 1383-1389, vol. 280.
Carpenter et al., Proc. Natl. Acad. Sci. USA, 1998, pp. 6061-6066, vol. 95.
Colas et al., The impact of two-hybrid and related methods on biotechnology, Trends in Biotechnology, Aug. 1998, pp. 355-363, vol. 16.
Eyckerman et al., Analysis of Tyr to Phe and fa/fa leptin receptor mutations in the PC12 cell line, Eur. Cytokine Netw, Dec. 1999, pp. 549-556, vol. 10, No. 4.
Fields et al., The two-hybrid system: an assay for protein-protein interactions, Trends in Genetics, Aug. 1994, pp. 286-292, vol. 10, No. 8.
Grasso et al., Endocrinol, 1997, pp. 1413-1418, vol. 138.
Ihle et al., Jaks and Stats in signaling by the cytokine receptor superfamily, Trends Genet., Feb. 1995, pp. 69-74, vol. 11, No. 2.
Medici et al., The EMBO Journal 1997, pp. 7241-7249, vol. 16, No. 24.
Montoye et al., Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy, FEBS Letters, 2006, pp. 3301-3307, vol. 580.
Montoye et al., In Press, A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian two-hybrid approach.
Ngo et al., The Protein Folding Problem and Tertiary Structure Prediction, Chapter 14: Computational Complexity Protein Structure Prediction, and the Levinthal Paradox, Mar. 2, 1994, pp. 492-495.
Okuda et al., Ann N Y Acad Sci, 1999, pp. 305-312, vol. 872.
Osborne et al., The Yeast Tribrid System—Genetic Detection of trans-phosphorylated ITAM-SH2-Interactions, Biotechnology, Dec. 13, 1995, pp. 1474-1478, vol. 13.
Overton et al., Current Biology, 2000, pp. 341-344, vol. 10, No. 6.
Rohner-Jearnrenaud et al., The New Eng. J. Med. 1996, pp. 324-325, vol. 334.
Saitoh et al., Identification of Important Regions in the Cytoplasmic Justamembrane Domain of Type I Receptor That Separate Signaling Pathways of Transforming Growth Factor-beta, The Journal of Biological.
Shores et al., Curr Opin Immunol 1997, pp. 380-389, vol. 9, No. 3.
Verploegen et al., FEBS Letters, 1997 pp. 237-240, vol. 405.
Wells, Additivity of Mutational Effects in Proteins, Biochemistry, Sep. 18, 1990, pp. 8509-8517, vol. 29, No. 37.
Broekaert Daniel
Tavernier Jan
Vandekerckhove Joël S.
Verhee Annick
Waelput Wim
Chandra Gyan
Landsman Robert S.
TraskBritt
Vlaams Interuniversitair Instituut Voor Biotechnologie VZW
LandOfFree
Leptin-mediated gene-induction does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Leptin-mediated gene-induction, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Leptin-mediated gene-induction will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3826436