Leptin antagonist

Details Leptin antagonist Leptin antagonist

2004-08-25

2008-09-09

Landsman, Robert S. (Department: 1646)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S326000, C514S012200

Reexamination Certificate

active

07423113

ABSTRACT:
The present invention relates to an antagonist or inhibitor of leptin signaling via the leptin receptor. The leptin antagonist binds to the leptin receptor, but is unable to induce JAK-STAT signal transduction via the leptin receptor. By binding to the leptin receptor, the leptin antagonist impairs binding of leptin to the leptin receptor and blocks leptin signaling.

REFERENCES:
patent: 5972621 (1999-10-01), Tartaglia et al.
patent: WO 97/00319 (1997-01-01), None
patent: WO 97/20933 (1997-06-01), None
patent: WO 98/12224 (1998-03-01), None
patent: WO 99/40946 (1999-08-01), None
patent: WO 02/40543 (2002-05-01), None
patent: WO 02/062833 (2002-08-01), None
Rohner-Jearnrenaud et al., The New Eng. J. Med., 334: 324-325, 1996.
Campfield et al., Science 280: 1383-1389, 1998.
Grasso et al., Endocrinol. 138: 1413-1418, 1997.
Verploegen et al., FEBS Letters 405, 237-240, 1997.
Bjorbaek et al., The Role of SOCS-3 in Liptin Signaling and Leptin Resistance, The Journal of Biological Chemistry, Oct. 15, 1999, pp. 30059-65, vol. 274, No. 42.
Bonnefoy-Berard et al., Vav: Function and Regulation in Hematopoietic Cell Signaling, Stem Cells, 1996, pp. 250-68, vol. 14.
Gisselbrecht, The CIS/SOCS proteins: a family of cytokine-inducible regulators of signaling, European Cytokine Network, Dec. 1999, pp. 463-70, vol. 10, No. 4.
Lee et al., Abnormal splicing of the leptin receptor in diabetic mice, Nature, Feb. 15, 1996, pp. 632-635, vol. 379.
Mercer et al., Localization of leptin receptor mRNA and the long form splice variant (ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization, FEBS Letters, 1996, pp. 113-16, vol. 387.
Tartaglia et al., Identification and Expression Cloning of a Leptin Receptor, OB-R, Cell, Dec. 29, 1995, pp. 1263-71, vol. 83.
Zabeau et al., The ins and outs of leptin receptor activations, FEBS Letters, 2003, pp. 45-50, vol. 546.

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