Leporin A, an antiinsectan fungal metabolite

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 89, C07D491052, A61K 3144

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active

052816095

ABSTRACT:
A novel N-methoxy-2-pyridone designated leporin A has been isolated from the sclerotia of the fungus, Aspergillus leporis. Leporin A is characterized by the structural formula ##STR1## and is effective for controlling Lepidopteran insect pests.

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TePaske et al. Tet. Lett. 32(41), pp. 5687-5690, 1991.
Gloer, James B., et al., "Antiinsectan Aflavinine Derivatives from the Sclerotia of Aspergillus flavus", J. Org. Chem., 1988, 53, pp. 5457-5460.
Wicklow, Donald T., et al., "Sclerotial metabolites of Aspergillus flavus Toxic to a Detritivorous Maize Insect (Carpophilus hemipterus, nitidulidae)", Trans. Br., Mycol. Soc., 91 (3), 1988, pp. 433-438.
Samson, Robert A., et al., "Typification of the Species of Aspergillus and Associated Telemorphs", Advances in Penicillium and Aspergillus Systematics, Plenum Press, N.Y., 1985, pp. 31-54.
American Type Culture Collection Catalogue of Fungi/Yeasts Seventeenth Edition, 1987, Jong, S. C. & Gant, M. J., editors, pp. 31-54.

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