Lepidopteran GABA gated chloride channel and nucleic acids encod

Details Lepidopteran GABA gated chloride channel and nucleic acids encod Lepidopteran GABA gated chloride channel and nucleic acids encod

1995-11-08

1998-06-16

Walsh, Stephen

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 530350, 435325, 435348, 43525411, 435 691, 4353201, 4352523, C07K 14705, C12N 510, C12N 1512

Patent

active

057672610

ABSTRACT:
The present invention provides isolated nucleic acids encoding lepidopteran gamma aminobutyric acid (GABA) gated chloride channels. In a preferred embodiment, the nucleic acids encoding lepidopteran GABA gated chloride channels are isolatable from Heliothis virescens. The invention further provides recombinant lepidopteran GABA gated chloride channels and methods for identifying agonists and antagonists to a lepidopteran GABA gated chloride channels.

REFERENCES:
patent: 5487976 (1996-01-01), Soderlund et al.
Anthony et al., "GABA receptor molecules of insects", in Comparative Molecular Neurobiology, Y. Pichon, Ed., Birkhauser Verlag (Basel, Switzerland), pp. 172-209, 1993.
Darlison et al., GABAA receptor subtypes: which, where and why?, Seminars Neurosci., 7: 115-126, 1995.
Malecot et al, "GABA receptors in the nervous system of an instect, Periplaneta americana", in GABA-B Receptrors in Mammalian Function, N. Bowery et al., Eds, John Wiley and Sons (New York), p. 431, 1990.
Chen et al., Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor, Proc. Natl. Acad. Sci. USA, 91: 6069-6073, Jun. 1994.
Ffrench-Constant et al., Molecular cloning and transformation of cyclodiene resistance in Drosophila: An invertebrate gamma-aminobutyric acid subtype A receptor locus, Proc. Natl. Acad. Sci. USA, 88: 7209-7213, Aug. 1991.
Lunt, GABA and GABA receptors in inverebrates, Seminars Neurosci., 3(3): 251-258, Jun. 1991.
Miyazaki et al., DNA sequence and site of mutation of the GABA receptor of cyclodiene-resistant red flour beetle, Tribolium castaneum, Comp. Boichem. Physiol., 111 B(3): 399-406, 1995.
Shotkoski et al., Functional expression of insecticide-resistant GABA receptors from the mosquito Aedes aegypti, Insect Mol. Biol., 3(4): 283-287, 1994.
Thompson et al., Cloning and sequencing of the cyclodiene insecticide resistance gene from the yellow fever mosquito aedes aegypti, FEBS, 325(3): 187-190, Jul. 1993.
Marullo et al., Expression of human B1 and B2 adrenergic receptors in E. coli as a new tool for ligand screening, Bio/Technology, 7:923-927, Sep. 1989.

Affiliated with

Also associated with

Rating

Lepidopteran GABA gated chloride channel and nucleic acids encod does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lepidopteran GABA gated chloride channel and nucleic acids encod, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lepidopteran GABA gated chloride channel and nucleic acids encod will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1727092