Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1989-08-04
1991-06-11
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 694, C12N 1516, C12N 1512
Patent
active
050233289
ABSTRACT:
A baculovirus expression vector system is constructed wherein the natural signal DNA peptide sequence associated with the desired foreign gene, such as CD4 (T cell surface protein T4) is replaced by the signal DNA sequence from the Lepidopteran adipokinetic hormone (AKH) precursor signal peptides. The exemplary Manduca sexta AKH signal sequence is represented as follows: ##STR1## .
REFERENCES:
patent: 4745051 (1988-05-01), Smith et al.
Wolfe, S., Biology of the Cell, Wadsworth Pub. Co., Belmont, Calif., 1972, p. 263.
Watson, J. et al., Recombinant DNA-A Short Course, Scientific American Books, New York, 1983, pp. 3 and 38.
Suggs S. U. et al., 1981 PNAS 78(11)6613-6617.
Bradfield et al., "Adipokinetic Hormone Gene Sequence from Manduca sexta," The Journal of Biological Chemistry, vol. 264(22):12791-12793 (1989).
Schulz-Allen et al., "Synthesis of a Homodimer Neurohormone Precursor of Locust Adipokinetic Hormone Studied by In Vitro Translation and cDNA Cloning," Neuron, vol. 2:1369-1373 (1989).
Susumu Maeda, "Expression of Foreign Genes in Insects Using Baculovirus Vectors," Ann., Rev. Entomol., vol. 34:351-72 (1989).
Schaffer et al., "Cloning of Adipokinetic Hormone cDNA," Society for Neuroscience Abstracts, vol. 14(1):29, Abstract No. 17.4 (1988).
Schulz et al., "Molecular Biological Studies on the Synthesis of Locust Adipokinetic Hormones," Society of Neuroscience Abstracts, vol. 14 (1):29, Abstract No. 17.5 (1988).
Hekimi et al., "Identification and Purification of Two Precursors of the Insect Neuropeptide Adipokinetic Hormone," The Journal of Neuroscience, vol. 7(9):2773-2784 (1987).
Summers et al., "A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures," Texas Agriculture Experiment Station Bulletin No. 1555.
Keeley et al., "Speculations on Biotechnology Applications for Insect Neuroendocrine Research," Insect Biochem., vol. 17(5):639-651 (1987).
Ziegler et al., "Amine Acid Sequence of Manduca sexta Adipokinetic Hormone Elucidated by Combined Fast Atom Bombardment (FAB)/Tandem Mass Spectrometry," Biochemical and Biophysical Research Communications, vol. 133(1):337-342 (1985).
Bradfield James Y.
Keeley Larry L.
Summers Max D.
Schwartz Richard A.
The Texas A&M University System
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