Lentiviral vectors derived from SIVsmm/PBj14, method for...

Details Lentiviral vectors derived from SIVsmm/PBj14, method for... Lentiviral vectors derived from SIVsmm/PBj14, method for...

2003-04-03

2010-06-01

Marvich, Maria B (Department: 1633)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093210, C435S320100, C435S069100, C435S455000, C435S252300

Reexamination Certificate

active

07727522

ABSTRACT:
The invention relates to retroviral vectors (known as lentiviral vectors), which are used to transfer genes into cells that are at cell cycle stage G0, to methods for their production and to the use thereof for transferring genes into mammalian cells. Said vectors are derived from SIVsmmPBj14 (simian immunodeficiency virus) of the sooty mangabey monkey, strain PBj 14.

REFERENCES:
patent: 5212084 (1993-05-01), McClure et al.
patent: 6013516 (2000-01-01), Verma et al.
Stephens et al, Simian-Human Immunodeficiency Virus (SHIV) Containing the nef/Long Terminal Repeat Region of the Highly Virulent SIVsmmPBj14 Causes PBj-Like Activation of Cultured Resting Peripheral Blood Mononuclear Cells, but the Chimera Showed No Increase in Virulence, J Virology, 1998, vol. 71(6), pp. 5207-5214.
Manrique et al, Functional relationship between the matrix proteins of feline and simian immunodeficiency viruses , Virology, 2004, vol. 329, pp. 157-167.

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