Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Reexamination Certificate
2007-11-09
2010-11-16
Saucier, Sandra (Department: 1651)
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
C435S173100
Reexamination Certificate
active
07833398
ABSTRACT:
Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a semiconductor substrate. One or more membranes are used in further embodiments. The low free-energy region is a larger chamber formed adjacent the high free-energy region. A recoil phase allows longer molecules not fully driven into the high free-energy region to recoil into the low free-energy region. In a further variation, the high free-energy region is a membrane having nanoscale holes.
REFERENCES:
patent: 5135627 (1992-08-01), Soane
patent: 5340452 (1994-08-01), Brenner et al.
patent: 5427663 (1995-06-01), Austin et al.
patent: 5599432 (1997-02-01), Manz et al.
patent: 5650055 (1997-07-01), Margolis
patent: 5651900 (1997-07-01), Keller et al.
patent: 5707799 (1998-01-01), Hansmann et al.
patent: 5800690 (1998-09-01), Chow et al.
patent: 5837115 (1998-11-01), Austin et al.
patent: 5842787 (1998-12-01), Kopf-Sill et al.
patent: 5882465 (1999-03-01), McReynolds
patent: 5904824 (1999-05-01), Oh
patent: 5938923 (1999-08-01), Tu et al.
patent: 5948227 (1999-09-01), Dubrow
patent: 5958694 (1999-09-01), Nikiforov
patent: 6042710 (2000-03-01), Dubrow
patent: 6043080 (2000-03-01), Lipshutz et al.
patent: 6093296 (2000-07-01), Soane et al.
patent: 6110339 (2000-08-01), Yager et al.
patent: 6132578 (2000-10-01), Kambara et al.
patent: 6156273 (2000-12-01), Regnier et al.
patent: 6186660 (2001-02-01), Kopf-Sill et al.
patent: 6193866 (2001-02-01), Bader et al.
patent: 6414043 (2002-07-01), Asher et al.
patent: 6454789 (2002-09-01), Chen et al.
patent: 6635163 (2003-10-01), Han et al.
patent: 6685810 (2004-02-01), Noca et al.
patent: 7316769 (2008-01-01), Craighead et al.
Chou, et al. Sorting by Diffusion: An Asymmetric Obstacle Course for Continuous Molecular Separation. Proc Natl Acad Sci U S A. Nov. 23, 1999;96(24):13762-5.
Deutsch, et al. Macromolecular separation through a porous surface. J. Chem. Phys. 1997;106(22): 9376-9381.
Han, et al. Entropic trapping and sieving of long DNA molecules in a nanofluidic channel. J. Vac. Sci. Technol. A 1999;17(4): 2142-2147.
Long, et al. Separation of polyelectrolytes by porous membranes permeation. C. R. Acad. Sci. Paris. 1995;321 (Series IIb): 239-246.
Nixon, et al. Entropic Trapping and electrophoretic drift of a polyelectrolyte down a channel with a periodically oscillating width. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. May 1996;53(5):4969-4980.
Viovy, J. L. Electrophoresis of DNA and other Polyelectrolytes: Physical Mechanisms. Reviews of Modern Physics. 2000;72(3): 813-872.
Volkmuth, et al. DNA electrophoresis in microlithographic arrays. Nature. 1992 Aug 13;358(6387):600-2.
Volkmuth, et al. Trapping of branched DNA in microfabricated structures. Proc Natl Acad Sci U S A. Jul. 18, 1995;92(15):6887-91.
Webster's II New Riverside Dictionary. Houghton-Mifflin: Boston, MA. 1994;p. 740.
Craighead Harold G.
Turner Stephen W.
Cornell Research Foundation Inc.
Hanley Susan
Saucier Sandra
Wilson Sonsini Goodrich & Rosati
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