Length-dependent recoil separation of long molecules

Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S173100

Reexamination Certificate

active

07316769

ABSTRACT:
Separation of long molecules by length is obtained by forcing such molecules to traverse a boundary between a low free-energy region and a high free-energy region. In one embodiment, the high free-energy region is a dense pillar region or other structure formed on a semiconductor substrate. One or more membranes are used in further embodiments. The low free-energy region is a larger chamber formed adjacent the high free-energy region. A recoil phase allows longer molecules not fully driven into the high free-energy region to recoil into the low free-energy region. In a further variation, the high free-energy region is a membrane having nanoscale holes.

REFERENCES:
patent: 5135627 (1992-08-01), Soane
patent: 5340452 (1994-08-01), Brenner et al.
patent: 5427663 (1995-06-01), Austin et al.
patent: 5599432 (1997-02-01), Manz et al.
patent: 5650055 (1997-07-01), Margolis
patent: 5651900 (1997-07-01), Keller et al.
patent: 5707799 (1998-01-01), Hansmann et al.
patent: 5800690 (1998-09-01), Chow et al.
patent: 5837115 (1998-11-01), Austin et al.
patent: 5842787 (1998-12-01), Kopf-Sill et al.
patent: 5882465 (1999-03-01), McReynolds
patent: 5904824 (1999-05-01), Oh
patent: 5938923 (1999-08-01), Tu et al.
patent: 5948227 (1999-09-01), Dubrow
patent: 5958694 (1999-09-01), Nikiforov
patent: 6042710 (2000-03-01), Dubrow
patent: 6043080 (2000-03-01), Lipshutz et al.
patent: 6093296 (2000-07-01), Soane et al.
patent: 6110339 (2000-08-01), Yager et al.
patent: 6132578 (2000-10-01), Kambara et al.
patent: 6156273 (2000-12-01), Regnier et al.
patent: 6186660 (2001-02-01), Kopf-Sill et al.
patent: 6193866 (2001-02-01), Bader et al.
patent: 6414043 (2002-07-01), Asher et al.
patent: 6454789 (2002-09-01), Chen et al.
patent: 6635163 (2003-10-01), Han et al.
patent: 6685810 (2004-02-01), Noca et al.
Han et al. “Entropic trapping and sieving of long DNA molecules in a nanofluidic channel” J. Vac. Sci. Technol. A 17(4): 2142-2147, Jul., Aug. 1999.
Webster's II New Riverside Dictionary (1994) (Houghton-Mifflin: Boston, MA) p. 740.
Viovy, J-L. “Electrophoresis of DNA and other Polyelectrolytes: Physical Mechanisms” Reviews of Modern Physics (Jul. 2000) 72(3): 813-872.
Long et al. “Separation of polyelectrolytes by porous membranes permeation” C. R. Acad. Sci. Paris. vol. 321, Series llb, p. 239-246 (1995).
Deutsch et al. “Macromolecular separation through a porous surface” J. Chem. Phys. 106(22): 9376-9381 (Jun. 8, 1997).
Chou, C. , et al., “Sorting by Diffusion: An Asymmetric Obstacle Course for Continuous Molecular Separation”,PNAS, 96 (24), (Nov. 23, 1999), pp. 13762-13765.
Nixon, G. I., et al., “Entropic Trapping and electrophoretic drift of a polyelectrolyte down a channel with a periodically oscillating width”,Physical Review E, 53 (5), (May 1996), pp. 4969-4980.
Volkmuth, W. D., et al., “DNA electrophoresis in microlithographic arrays”,Nature, 358, (Aug. 13, 1992), pp. 600-602.
Volkmuth, W. D., et al., “Trapping of branched DNA in microfabricated structures”,PNAS, 92 (15), (Jul. 1995), pp. 6887-6891.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Length-dependent recoil separation of long molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Length-dependent recoil separation of long molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Length-dependent recoil separation of long molecules will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2803263

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.