Lectin-like domain of thrombomodulin and its therapeutic use

Details Lectin-like domain of thrombomodulin and its therapeutic use Lectin-like domain of thrombomodulin and its therapeutic use

2008-03-11

2008-03-11

Tsang, Cecilia (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07341992

ABSTRACT:
The in vivo role of the N-terminal lectin-like domain of thrombomodulin was studied by using homologous recombination in murine ES cells to create mutant mice that lack this region of thrombomodulin. Phenotypic analysis shows that said mice respond identically to their wild type littermates following pro-coagulant challenges meaning that the protein C pathway is not altered by the mutation. However, following several inflammatory stimuli, it was observed that the mutant mice showed an elevated neutrophil extravasation in several organs. It is found that leukocyte adhesion could be abrogated by addition of recombinant lectin-domain meaning that said domain has direct anti-inflammatory properties which means that the lectin-like domain can be used to manufacture a medicament useful for the treatment of a variety of inflammatory disease processes.

REFERENCES:
patent: 6500646 (2002-12-01), Kuriyama et al.
patent: 2004/0077552 (2004-04-01), Luger
patent: 1 390 407 (2005-09-01), None
patent: 2000053582 (2000-02-01), None

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