Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1992-12-21
1995-09-26
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241851, 530329, 530868, 514885, 436827, C07K 706
Patent
active
054532728
ABSTRACT:
The invention is directed to a lectin derived carbohydrate binding-peptide which inhibits cell-mediated immune responses and has the amino acid sequence SPYGRC. The peptide binds terminally linked .alpha.-sialic acid (2.fwdarw.3).beta.Gal- and .alpha.-sialic (2.fwdarw.6).beta.Gal-structures and is a acid fragment of the S2 subunit of pertussis toxin produced by Bordetella pertussis.
REFERENCES:
patent: 5079353 (1992-01-01), Ratcliffe et al.
patent: 5081034 (1992-06-01), Bevilacqua et al.
patent: 5154923 (1992-10-01), Van Eden et al.
patent: 5157023 (1992-10-01), Lipton
patent: 5198424 (1993-03-01), McEver
Seabrook et al Mol. Immunol. 27(8):777-785, 1990.
Heerze et al, Biochem Biophys Res Comm. 172: 1224-1229, 1990.
Walz et al, Science 250: 1132-1135, 1990.
McEver, "Leukocyte Interactions Mediated by GMP-140" in Cellular & Molecular Mechanisms of Inflammation vol. 2 pp. 15-29, 1991.
Roitt I. M et al Immunology C. V. Moshy Co. 1985, p. 19.1.
Bevilacqua et al "Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1: A Vascular Selectin that regulates Inflammation." In Cellular and Molecular Mechanisms of Inflammation vol. 2 Academic Press pp. 1-3, 1991.
Repine J. E. Lancet 339: 466-469, 1992.
Wright et al, J. Biol. Chem 261(6): 7191-7195, 1986.
Wright J. J. Mol. Biol 215: 635-651, 1990.
Albelda, et al., In "Integrins and other cell adhesion molecules" The FASEB Journal. 4:2868-2880 (1990).
Aplin, et al., "Complex Carbohydrates of The Extracellular Matrix Structures, Interactions and Biological Roles" Biochim. Biophys. Acta 694:375-418. (1982).
Armstrong, et al., "Maintenance of Biological Activity of Pertussis toxin Radioiodinated While Bould to Fetuin-Agarose" Infect. Immun., 55:1294-1299 (1987).
Armstrong, et al., "Use of Glycosyltransferases to Restore Pertussis Toxin Receptor Activity to Asialoagalactofetuin" J. Biol. Chem., 263:8677-8684 (1988).
Barondes, "Developmentally Regulated Lectins". In Cell Interactions and Development: Molecular Mechanisms (Yamada, D. M., Ed.) pp. 185-202 (1983).
Bhavanandan, et al., "The Interaction of Wheat Germ Agglutinin with Sialoglycoproteins" J. Biol. Chem., 254:4000-4008 (1979).
Brandley, et al., "Cell-Surface Carbohydrates in Cell Recognition and Response" J. Leukocyte Biol., 40:97-111 (1986).
Brennan, et al., "Lectin-like binding of Pertussis Toxin to a 165-Kilodalton Chinese Hamster Ovary Cell Glycoprotein" J. Biol. Chem., 263:4895-4899 (1988).
Chou, et al., "Empirical Predictions of Protein Conformation" Annu. Rev. Biochem., 47:251-276 (1978).
Coutinho, et al., "T. Cell-Dependent B Cell Activation" Immunol. Rev., 78:211-224 (1984).
Ekblom, et al., "The Extracellular Matrix and Kidney Differentiation" In Membranes in Growth and Development, Hoffmann et al., Eds., pp. 429-442, (1982).
Frazier, et al., "Surface Components and Cell Recognition" Annu. Rev. Biochem., 48:491-523 (1979).
Furukawa, et al., "Interaction of Sialoglycoproteins with Wheat Germ Agglutinin-Sepharose of Varying Ratio of Lectin to Sepharose" J. Biol. Chem., 261:7755-7761 (1986).
Glaser, "From Cell Adhesion to Growth Control" Mediator of Developmental Processes, (Substency, S. and Wessels, N. K., Eds.), pp. 79-97, (1980).
Hakomori, "Aberrant Glycosylation in Tumors and Tumor-Associated Carbohydrate Antigens" Adv. Cancer Res., 52:257-331 (1989).
Heerze, et al., "Comparison of the Lectin-Like Activity of Pertussis Toxin with Two Plant Lectins That Have Differential Specificities for .alpha.(2-6) And .alpha.(2-3)-Linked Sialic Acid" Biochem and Biophys. Res. Comm., 172:1224-1229 (1990).
Heerze, et al., "Synthesis and Characterization of a Pertussis Toxin-Biotin Conjugate" Biochem and Biophys. Res. Comm., 179:1464-1469 (1991).
Heerze, et al., "Investigation of the Lectin-like Binding Domains in Pertussis Toxin Using Synthetic Peptide Sequences", J. Biol. Chem., 268:1-6 (1993).
Hogg, "Roll, roll, roll your leucocyte gently down the vein . . . ", Immunology Today, 13:113-115 (1992).
Hopp, et al., "Prediction of Protein Antigenic Determinants from Amino Acid Sequences" Proc. Natl. Acad. Sci. U.S.A., 78:3824-3828 (1981).
Jacobson, "Beginnings of the Nervous System" Developmental Neurobiology, New York, Plenum Press pp. 5-25, (1978).
Karlsson, "Animal Glycosphingolipids as Membrane Attachment Sites For Bacteria" Annu. Rev. Biochem., 58:309-350 (1989).
Larsen, et al., "PADGEM-Dependent Adhesion of Platelets to Monocytes and Neutrophils is Mediated by a Lineage-Specific Carbohydrate LNF III (CD15)" Cell, 63:467-474 (1990).
Larsen, et al., "P-selectin and E-selectin" J. Biol. Chem., 267:11104-11110 (1992).
Lowe, et al., "ELAM-1-Dependent Cell Adhesion to Vascular Endothelium Determined by a Transfected Human Fucosyltransferase cDNA" Cell, 63:475-485 (1990).
McEver, "Leukocyte Interactions Mediated by GMP-140" In Cellular and Molecular Mechanisms of Inflammation, vol. 2, pp. 15-29 (1991).
Morgan, et al., "Approaches to the Discovery of Non-Peptide Ligands for Peptide Receptors and Peptidases", In Annual Reports in Medical Chemistry. 24:243-252 (1989).
Munoz, "Action of Pertussigen (Pertussis Toxin) on the Host Immune System." In Pathogenesis and Immunity in Pertussis, pp. 173-192 (1988).
Neuberger A., "What Lectins and Carbohydrates are Made For?" Biol. Cell, 51 (Special Issue), 113-114, 1984.
Nicolson, et al., "Preferential Organ Attachment and Invasion in vitro by B16 Melanoma Cells Selected for Differing Metastatic Colonization and Invasive Properties" Invas. Metas., 5:144-158 (1985).
Nogimori, et al., "Structure-Function Relationship of Islet-Activating Protein Pertussis Toxin: Biological Activities of Hybrid Toxins Reconstituted from Native and Methylated Subunits" Biochemistry, 25:1355-1363 (1986).
Paulson, "Interactions of Animal Viruses with Cell Surface Receptors" In The Receptors, vol. II (Comm., P. M., Ed.), pp. 131-219 (1985).
Pearce-Pratt, et al., "Simple Calorimetric Cell-Cell Adhesion Assay Using Biotinylated Lymphocytes" J. Imm. Methods, 140:159-165 (1991).
Phillips, et al., "ELAM-1 Mediates Cell Adhesion by Recognition of a Carbohydrate Ligand Sialyl-Le.sup.x " Science, vol. 250:1130-1132 (1990).
Reuter et al. Schauer Editor, "Sialic Acids", In Cell Biology Monographs, vol. 10 Schauer, Ed. (1982).
Reuter, et al, "Suggestions on the Nomenclature of Sialic Acids" Glycoconjugates 5:133-135 (1988).
Sato, et al., "Bordetella Pertussis Infection in Mice: Correlation of Specific Antibodies Against Two Antigens, Pertussis Toxin, and Filamentous Hemagglutinin with Mouse protectivity in an Intracerebral for Aerosol Channel System" Infect. Immun., 46:415-421 (1986).
Schwartz, et al., "Interaction Between Antigen-Presetting Cells and Primed T Lymphocytes: An Assessment of Ir Gene Expressions in the Antigen-Presenting Cell" Immunol. Rev., 40:153-180 (1978).
Sharon, "Lectin-Like Bacterial Adherence to Animal Cells" In Attachment of Microorganisms to the Gut Mucosa, (Boeheker, E. D., Ed.), pp. 129-147 (1984).
Sleytr, et al., "Structural and Chemical Characterization of S-layers of Selected Strains of Bacillus stearothermophilus and Desulfotomaculum nigrificans" Arch. Microbiol., 146:19-24 (1986).
Smets, et al., "Tumor Cell Surface Carbohydrate", In Membranes in Tumor Growth, Galeotti, et al., Eds., pp. 77-81, (1982).
Smith, et al., "Cyclophosphamide and Dimethyl Dioctadecyl Ammonium Bromide Immunopotentiate the Delayed-Type Hypersensitivity Response to Inactivated Enveloped Viruses" Immunology, 58:245-250 (1986).
Smith, et al., "Induction of Delayed-Type Hypersensitivity to Measles Virus in Mice" Cell. Imm., 89:20-29 (1984).
Springer, et al., "Sticky Sugars for Selectins" Nature, 349:196-197 (1991).
Tamura, et al., "A Role of the B-Oligomer Moiety of Islet-activating Protein, Pertussis Toxin, in Development of Biological Effects on Intact Cells" J. Biol. Chem., 258:6756-6761 (1983).
Trinkaus, "The Molecular Structure of the Cell Surface" Cells into Organs, pp. 44-68, (1984).
Tuomanen, et al., "Preceptor Analogs and Monoclonal Antibodies That Inhibit Adherence of Bordetella Pertussis To Human Ciliated Respiratory Epithelial Cells" J. Exp. Med., 168:267-277 (1988).
Tuommenen, et al., "Bac
Armstrong Glen D.
Heerze Louis D.
Smith Richard
Alberta Research Council
Dillahunty Mary Ann
Krsek-Staples Julie
Nucker Christine M.
Swiss Gerald F.
LandOfFree
Lectin derived carbohydrate binding-peptide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Lectin derived carbohydrate binding-peptide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lectin derived carbohydrate binding-peptide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1551063