Lectin compositions and methods for modulating an immune...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023400, C424S192100

Reexamination Certificate

active

07629440

ABSTRACT:
The present invention relates to a fusion polypeptide comprising at least about 10 contiguous amino acid residues of an influenza virus hemagglutinin and at least about 5 contiguous amino acids of a naturally occurring GM-CSF molecule.

REFERENCES:
patent: 5882650 (1999-03-01), Ennis
patent: 5891432 (1999-04-01), Hoo
patent: 6277368 (2001-08-01), Hiserodt et al.
Faulkner, L. et al. IL-2 linked to a peptide from influenza hemagglutinin enhances T cell activation by affecting the antigen-presentation function of bone marrow-derived dendritic cells. Int Immunol. Jun. 2001;13(6):713-21.
Rodriguez, D. et al. A human immunodeficiency virus type 1 Env-granulocyte-macrophage colony-stimulating factor fusion protein enhances the cellular immune response to Env in a vaccinia virus-based vaccine. J Gen Virol. Jan. 1999;80 ( Pt 1):217-23.
Batova, A. et al. The Ch14.18-GM-CSF fusion protein is effective at mediating antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity in vitro. Clin Cancer Res. Dec. 1999;5(12):4259-63.
Chen, T.T. et al. ldiotype-cytokine fusion proteins as cancer vaccines. Relative efficacy of IL-2, IL-4, and granulocyte-macrophage colony-stimulating factor. J lmmunol. Nov. 15, 1994;153(10):4775-87.
Babai, I. et al. A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin
euraminidase and IL-2 or GM-CSF. I. Vaccine characterization and efficacy studies in mice. Vaccine. Mar. 5, 1999;17(9-10):1223-38.
Babai, I. et al. A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin
euraminidase and IL-2 or GM-CSF. II. Induction of TH1 and TH2 responses in mice. Vaccine. Mar. 5, 1999;17(9-10):1239-50.
Fields et al., Virology, Third Edition (1996).
Wortham et al., “Enhanced Protective Antibody Responses to PspA after Intranasal or Subcutaneous Injections of PspA Genetically Fused to Granulocyte-Macrophage Colony Stimulating Factor or Interleukin-2,” Infection and Immunity, vol. 66, No. 4, pp. 1513-1520 (1998).
Babai et al. Vaccine 20:505-515, 2002.
Burbage, et al., Ricin Fusion Toxin Targeted To The Human Granulocyte-Macrophage Colony Stimulating Factor Receptor Is Selectively Toxic To Acute Myeloid Leukemia Cells,Leukemia Researchvol. 21, No. 7, pp. 681-690, 1997.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Lectin compositions and methods for modulating an immune... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Lectin compositions and methods for modulating an immune..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Lectin compositions and methods for modulating an immune... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4069346

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.