Leader-proteinase deleted foot-and-mouth disease viruses and the

Details Leader-proteinase deleted foot-and-mouth disease viruses and the Leader-proteinase deleted foot-and-mouth disease viruses and the

1996-05-24

1998-10-20

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

435236, A61K 39135, C12N 704

Patent

active

058243160

ABSTRACT:
A foot-and-mouth disease virus has been genetically engineered by deleting the nucleic acid sequence encoding the leader (L) proteinase from an infectious cDNA copy of the viral genome and producing an L proteinase-deleted virus. The L proteinase-deleted viruses are able to assemble and grow in cells in culture, but, since they lack L proteinase, they are less toxic to infected cells within the animal, producing an attenuated infection. The recombinant virus can be formulated into an effective vaccine for the prevention of foot-and-mouth disease.

REFERENCES:
Kirchweger et al., J. Virology, 68(9), pp. 5677-5687 (1994).
Piccone et al., Ivth International Positive Strand RNA Virus Symposiu, May 25-30, 1995, Official Abstract Form.
Piccone et al., J. Virology, 69(9), pp. 5376-5382 (1995).

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