Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Patent
1993-12-20
1996-05-14
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
424451, 424464, 424489, 4241951, 424 7801, 514892, A61K 916, A61K 920, A61K 948, A61K 3578
Patent
active
055165249
ABSTRACT:
An ingestible laxative composition comprising specified amounts of dioctyl sulfosuccinate and bulk fiber selected from the group consisting of psyllium, methylcellulose, polycarbophil, calcium polycarbophil, bran, malt soup extract, karaya, guar gum, and mixtures thereof, preferably in single dose form, is described.
REFERENCES:
patent: 2764590 (1956-09-01), Kottler et al.
patent: 3927195 (1975-12-01), Messora
patent: 4005196 (1977-01-01), Jandacek et al.
patent: 4321263 (1982-03-01), Powell et al.
patent: 4459280 (1984-07-01), Colliopoulos et al.
patent: 4511561 (1985-04-01), Madaus et al.
patent: 4548806 (1985-10-01), Colliopoulos et al.
patent: 4834985 (1989-05-01), Elger et al.
patent: 4911889 (1990-03-01), Leland et al.
patent: 4942042 (1990-07-01), Bhargava et al.
patent: 4952402 (1990-08-01), Sparks et al.
patent: 5034378 (1991-07-01), Cox
patent: 5068110 (1991-11-01), Fawzi et al.
patent: 5149541 (1992-09-01), Leis, Jr. et al.
patent: 5219570 (1993-06-01), Barbera
patent: 5229117 (1993-07-01), Leland et al.
patent: 5232698 (1993-08-01), Hord
patent: 5234916 (1993-08-01), Hord
Adels, Morton J., M.D., "Relative Efficacy of Three Laxatives In Postpartum Hospital Use", Delaware Medical Journal, (Jul. 1974), 346-349.
Anderberg, Eva Karin, Christer Nystrom and Per Artursson, "Epithelial Transport of Drugs in Cell Culture. VII: Effects of Pharmaceutical Surfactant Excipients and Bile Acids on Transepithelial Permeability in Monolayers of Human Intestinal Epithelial (Caco-2) Cells", Journal of Pharmaceutical Sciences, vol. 81, No. 9 (Sep. 1992), 879-887.
Bretagne, J. F., N. Vidon, CH L'Hirondel, and J. J. Bernier, "Increased Cell Loss in the Human Jejunum Induced by Laxatives (Ricinoleic Acid, Dioctyl Sodium Sulphosuccinate, Magnesium Sulphate, Bile Salts)", Gut. 22 (1981), 264-269.
Case, Marvin T. DVM PhD., J. Knox Smith MS and Robert A. Nelson DVM, "Acute Mouse and Chronic Dog Toxicity Studies of Danthron, Dioctyl Sodium Sulfosuccinate, Poloxalkol and Combinations", Drug and Chemical Toxicology, 1(1) (1977-78), 89-101.
Chapman, R. W., J. Sillery, D. D. Fontana, C. Matthys, and D. R. Saunders, "Effect of Oral Dioctyl Sodium Sulfosuccinate on Intake-output Studies of Human Small and Large Intestine", Gastroenterology (1985): 89; 489-93.
Curry, Clarence E., Jr., and Demetris Tatum-Butler, "Laxative Products", Handbook of Nonprescription Drugs, 10th ed. (1993), 219-225.
Donowitz, Mark, M.D. and Henry J. Binder, M.D., "Effect of Dioctyl Sodium Sulfosuccinate on Colonic Fluid and Electrolyte Movement", Gastroenterology, vol. 69, No. 4, (1975), 941-950.
Fain, Allen M., MD, Rosemary Susat, MD, Margaret Herring and Karen Dorton, "Treatment of Constipation in Geriatric and Chronically III Patients: A Comparison", Southern Medical Journal, 71 (1978). 677-680.
Fincher, Julian H., "Particle Size of Drugs and its Relationship to Absorption and Activity", Journal of Pharmaceutical Sciences (Nov. 1968), vol. 57, No. 11; 1825-1835.
Gaginella, T. S., PhD, J. C. Lewis, PhD, and S. F. Phillips, MD, "Rabbit lleal Mucosa Exposed to Fatty Acids, Bile Acids, and Other Secretagogues", Digestive Diseases (Sep. 1977), vol. 22, No. 9; 781-790.
Gullikson, Gary W., Mark Sender and Paul Bass, "Laxative-Like Effects of Nonsteroidal Anti-Inflammatory Drugs on Intestinal Fluid Movement and Membrane Integrity", The Journal of Pharmacology and Experimental Therapeutics, vol. 220, No. 2 (1982), 236-242.
Jauch, R., R. Hankwitz, K. Beschke and H. Pelzer, "Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The Common Laxative Principle of Bisacodyl and Sodium Picosulfate", Arzneim.-Forsch. (Drug Res.) 25, Nr. 11 (1975), 1796-1800.
Khalafallah, Nawal, M. Wafik Gouda and Said A. Khalil, "Effect of Surfactants on Absorption through Membranes IV: Effects of Dioctyl Sodium Sulfosuccinate on Absorption of a Poorly Absorbable Drug, Phenolsulfonphthalein, in Humans", Journal of Pharmaceutical Sciences, vol. 64, No. 6 (Jun. 1978), 991-994.
Kamm, M. A., J. E. Lennard Jones, D. G. Thompson, R. Sobnack, N. W. Garvie, and Marie Granowska, "Dynamic Scanning Defines a Colonic Defect in Severe Idiopathic Constipation", Gut. (1988), 29; 1085-1092.
Leng-Peschlow, Elke, "Effects of Sennosides A+B and Bisacodyl on Rat Large Intestine", Pharmacology (1989), 38; 310-318.
Lish, Paul M. and Kendrick W. Dungan, "Peristaltic-Stimulating and Fecal-Hydrating Properties of Dioctyl Sodium Sulfosuccinate, Danthron, and Cascara Extracts in the Mouse and Rat", American Pharmaceutical Association 47 (1958), 371-375.
Lish, Paul M., PhD., "Some Pharmacologic Effects of Dioctyl Sodium Sulfosuccinate on the Gastrointestinal Tract of the Rat", vol. 41, No. 6 (Dec. 1961), 580-584.
Lorenz, Egon, Michael B. Shimkin, Harold L. Stewart, "Preparations of Dispersions of Carcinogenic Hydrocarbons and Hormones with the Aid of Dioctyl Ester of Sodium Sulfosuccinate (Aerosol O.T.)", Journal of the National Cancer Institute, 355-360 Jan. 1939.
Lundholm, Lennart and Nils Svedmyr, "The Influence of Dioctyl Sodium Sulfosuccinate on the Laxative Action of some Anthraquinone Derivatives", Acta Pharmacol. Toxicol. 15 (1959) 373-383.
MacKenzie, K., S. Henwood, G. Foster, F. Akin, R. Davis, P. DeBaecke, G. Sisson, G. McKinney, "Three-Generation Reproduction Study with Dioctyl Sodium Sulfosuccinate in Rats", Fundamental and Applied Toxicology 15 (1990), 53-62.
Malik, Shah N., Donald H. Canaham and M. Wafik Gouda, "Effect of Surfactants on Absorption through Membranes III: Effects of Dioctyl Sodium Sulfosuccinate and Poloxalene on Absorption of a Poorly Absorbable Drug, Phenolsulfonphthalein, in Rats", Journal of Pharmaceutical Sciences, vol. 64, No. 6 (Jun. 1978), 987-990.
Moriarty, K. J., M. J. Kelly, R. Beetham and M. L. Clark, "Studies on the Mechanism of Action of Dioctyl Sodium Sulphosuccinate in the Human Jejunum", Gut. (1985), 26, 1008-1013.
Porro, G. Bianchi, M. Petrillo, A. Prada, "Endoscopy in Dypepsia", British Society for Digestive Endoscopy; Memorandum on Further National Needs for Fiberoptic Endoscopy of the Gastrointestinal Tract, British Medical Journal (Mar. 1975).
Preston, D. M., MRCP and J. E. Lennard-Jones, FRCP, "Pelvic Motility and Response to Intraluminal Bisacodyl in Slow-Transit Constipation", Digestive Diseases and Sciences, vol. 30, No. 4 (Apr. 1985), 289-294.
Roth, W. and K. Beschke, "Pharmacokinetics and Laxative Effect of Bisacodyl after Administration of Various Dosage Forms" (translation), Arzneim.-Forsch./Drug Res. V. 38(1), #4 (1988), 570-574.
Saunders, D. R., M. D., J. Sillery and D. Rachmilewitz, M.D., "Effect of Dioctyl Sodium Sulfosuccinate on Structure and Function of Rodent and Human Intestine", Gastroenterology (1975), vol. 69, No. 2; 380-386.
Sigma chemical catalogue, 1537-39 Jan. 1983.
Stewart, Ronald B., MS and Leighton E. Cluff, MD, "Gastrointestinal Manifestations of Adverse Drug Reactions", The American Journal of Digestive Diseases, vol. 19, No. 1 (Jan. 1974) 1-7.
Whistler, Roy L. and James N. BeMiller, Industrial Gums: Polysaccharides and Their Derivatives, 3rd Ed. (1993), Chapters 5-8, 13, 18, 20.
Federal Register, Department of Health, Education and Welfare, Food and Drug Administration, "Over-the-Counter Drugs-Proposed Establishment of Monographs for OTC Laxative, Antidiarrheal, Emetic and Antiemetic Products," Mar. 21, 1975, vol. 40, No. 56, Part II.
Pharmacology and Therapeutics, Grollman et al., 1970, pp. 532-537.
Facts and Comparisons, Kastrup et al., Oct. 1984, pp. 322-323c.
Kais Theresa M.
Sagel Paul J.
Mohl Douglas C.
Page Thurman K.
Poland Mary Catherine
Rasser Jacobus C.
Spear James M.
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