Lawsonia derived gene and related hemolysin polypeptides,...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S190100, C424S185100, C424S184100, C536S023100, C536S023700, C435S069300, C435S069700, C530S300000, C530S350000

Reexamination Certificate

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07029683

ABSTRACT:
The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated byLawsonia intracellularisor similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived fromLawsonia intracellulariswhich encodes an immunogenic hemolysin peptide, polypeptide or protein that is particularly useful as an antigen in vaccine preparation for conferring humoral immunity againstLawsonia intracellularisand related pathogens in animal hosts. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detectingLawsonia intracellularisor similar or otherwise related microorganisms.

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