Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is organic
Patent
1987-11-09
1989-07-11
Nucker, Christine M.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is organic
422 61, 436 67, 436534, 436808, 436825, 436826, G01N 33546, G01N 3372
Patent
active
048472093
ABSTRACT:
A latex agglutination immunoassay method for determining an analyte in a blood sample in which the pH of the reaction mixture is maintained at about 8.5 or greater in order to overcome nonspecific agglutination of latex particles by hemoglobin present in the sample. The method is particularly applicable to the determination of glycated hemoglobin, e.g., Hb Alc. In another embodiment, native hemoglobin (Ao) can be determined based on its ability to cause agglutination of latex particles suspended in an aqueous solution having a pH of about 8 or below.
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Gribnau et al, "Particle-Labelled Immunoassays: A Review", J. Chromatog. 376 (1986) 175-189.
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Masson et al, "Particle counting immunoassay- an overview", J. Pharm. Biomed. Anal., 5 (1987) 113-117.
Goldstein et al, "Glycated Hemoglobin: Methodologies and Clinical Applications", Clin. Chem., 32 (1986) B64-B70.
Lewis Lynette A.
Messenger Lowry
Yeager Frances M.
Yip Kin F.
Klawitter Andrew L.
Miles Inc.
Nucker Christine M.
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