Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1988-08-10
1990-07-24
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435805, 435810, 436512, 436514, 436518, 436520, 436523, 436531, 436535, 436807, 436808, 436810, 422 55, 422 56, 422 57, 422 58, 422101, G01N 3353
Patent
active
049435221
ABSTRACT:
A method and apparatus for conducting specific binding pair assays, such as immunoassays, is described. A porous membrane capable of non-bibulous lateral flow is used as assay substrate; a member of the binding pair is affixed in an indicator zone defined in the substrate. The sample is applied at a position distant from the indicator zone and permitted to flow laterally through the zone; any analyte in the sample is complexed by the affixed specific binding member, and detected. A novel method of detection employs entrapment of observable particle in the complex. Blood is a particularly preferred sample as the red blood cells can be used as the observable particles for detection of the complex.
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patent: 4740475 (1988-04-01), Paul
Eisinger Robert W.
Katz David H.
Khalil Mohammed H.
Sargeant Robert B.
Kepplinger Esther M.
Quidel
Spiegel Carol A.
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