Latent isocynate derivatives useful for deactivating enzymes

Details Latent isocynate derivatives useful for deactivating enzymes Latent isocynate derivatives useful for deactivating enzymes

1987-11-06

1990-05-29

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514335, 514346, 514396, 514399, 514423, 514546, 514576, 546243, 546262, 548530, 560 12, 560149, 562430, C07D23354

Patent

active

049297368

ABSTRACT:
Certain amino-acid derivatives are disclosed as effective inhibitors of human leukocyte elastase and therefore useful in preventing the imbalance of this proteolytic enzyme in vivo. The compounds specifically are derivatives L-valine, L-norvaline, L-norleucine, and L-methionine methyl ester azolides succinimides or pyridones and sulfonate salts, and related compounds such as L-leucine and L-phenylalanine methyl ester derivatives. The compounds were found to be excellent inhibitors in that they embody both inhibitory and anti-oxidant or anti-inflammatory activity.

REFERENCES:
Groutas et al., "Journal of Medicinal Chemistry", 28(2), pp. 204-209, 1985.

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