Latency active herpes virus promoters and their use

Details Latency active herpes virus promoters and their use Latency active herpes virus promoters and their use

1995-03-08

1998-12-15

Crouch, Deborah

Chemistry: molecular biology and microbiology

Vector, per se

4351723, 935 57, C12N 1500

Patent

active

058495711

ABSTRACT:
The application discloses the structure of a herpes virus promoter that by means of which one can obtain the transcription of a non-herpes gene in a cell latently infected with a herpes virus. An HSV-1 vector comprising a LAP2 promoter encoded by SEQ ID NO:1, or fragments of SEQ ID NO:1 which have LAP 2 promoter activity regulating the expression of a heterologous gene is particularly disclosed. The herpes virus is preferably used to obtain such expression in the neurons of the peripheral nerves, and the ganglion cells of the cranial nerves. The invention teaches that specific diseases and pathological conditions and the corresponding non-herpes genes wherein such expression has practical value.

REFERENCES:
patent: 4970155 (1990-11-01), Okasinski
patent: 5672344 (1997-09-01), Kelley et al.
patent: 5674722 (1997-10-01), Mulligan et al.
E. Marshall (1995) Science 269:1050-1055.
Vile et al (1995) Targeted Gene Therapy 9:190-199.
Chen et al., "Alternative Promoters for the Latency-Associated Transcripts f HSV-1" (Abstract 388), 19.sup.th International Herpesvirus Workshop, Vancouver, B.C. (Jul.-Aug., 1991).
French et al., "Identification of Cis-and Trans-Acting Elements in the TATA-less Latency Active Promoter of Herpes Simplex Type-1" (Abstract 386), 19.sup.th International Herpesvirus Workshop, Vancouver, B.C. (Jul.-Aug., 1991).
Glorioso et al, "Developments of Herpes Simplex Virus Vectors for Gene Transfer to the General Nervous System" pp. 281-302, in Gene Therapeutics: Methods and Application of Direct Gene Transfer, (J.A. Wolff,, ed.) (Birkhauser, 1995).
Glorioso et al, "Herpes Simplex Virus Vectors and Gene Transfer to Brain" pp. 79-87, in Recombinant Vectors in Vaccine Development, vol. 82 (F. Brown, ed.) (Dev. Biol. Stand., 1994).
Glorioso et al., "Developments of Herpes Simplex Virus as a Gene Transfer Vector for the Central Nervous System," pp. 133-145, in Gene Transfer and Therapy in the Nervous System (Gage & Christian, eds.) (Springer-Verlag, 1992).
Glorioso et al., Seminars in Virol., 3, 265-76 (1992).
Goins et al., "Characterization and Expression of the Herpes Simplex Virus Latency Specific Promoter in Neuronal Tissue" (Abstract), 14.sup.th International Herpesvirus Workshop, Nyborg Strand, Denmark, (1989).
Goins et al., "Characterization of a Novel TATAless Latency Active Promoter of Herpes Simplex Virus Type-1" (Abstract 8B-02), 18.sup.th International Herpesvirus Workshop, Pittsburgh Pennsylvania (Jul., 1993).
Goins et al., Abstract B405, J. Biol. Chem., Suppl., 15A, 199 (1991).
Goins et al., J. Virol., 68(4), 2239-52 (1994).
Ramakirshnan et al., J. Virol., 68(3), 1864-73 (1994).
Sternberg et al., "HSV-Mediated Gene Transfer into Rat CNS" (Abstract 8B-02), 16.sup.th International Herpesvirus Workshop, Pacific Grove, California (Jul., 1991).
Lokensgard et al., J. Virol., 68(11), 7148-58 (1994).
Glorioso et al., Annals of Neurology, 35 S28-S34 (1994).
Margolis et al., Virology, 197, 585-92 (1993).
Efstathiou, S. et al., J. Gen. Virol., 70, 869-879 (1989).
Efstathiou, S. et al., J. Virol., 57, 446-455 (1986).
Fink, D.J. et al., Ann. Neurol., 28, 220 (1990).
Fink, D.J. et al., Soc. Neurosci. Abstr., 16, 964 (1990).
Frame, M.C. et al., J. Gen. Virol., 68, 2699-2704 (1987).
Freese, A. et al. Biochem. Pharmacol., 40, 2189-2199 (1990).
Friedmann, T., Science, 244, 1275-1280 (1989).
Frink et al., J. Virol., 45, 634-647 (1983).
Geller, A. et al., Science, 241, 1667-1669 (1988).
Gorman, C.M. et al., Mol. Cell. Biol. 2, 1044-1051 (1982).
Hill, J.M. et al., Virology, 174, 117-125 (1990).
Hill, T.J., "The Herpesviruses" pp. 174-240, Plenum Press, New York (1985).
Ho, D.Y. et al., Proc. Natl. Acad. Sci. USA, 86, 7596-7600 (1989).
Homa, F.L. et al., Mol. Cell. Biol., 6, 3652-3666 (1986).
Homa, F.L. et al., Genes and Development , 2, 40-53 (1988).
Honess, R.W. et al., Proc. Natl. Acad. Sci. USA, 72, 1276-1280 (1975).
Honess, R.W. et al., J. Virol., 14, 8-19 (1974).
Jalanko, A. et al., Gene, 78, 287-296 (1989).
Leib, D.A. et al., J. Virol., 63, 2893-2900 (1989).
Mann, R. et al., Cell, 33, 153-159 (1983).
McFarland, D.J. et al., J. Nuerol. Sci., 72, 307-318 (1986).
McGeoch, et al., J. Mol. Biol., 181, 1-13 (1985).
Mellerick, D.M. et al., Virology, 158, 265-275 (1987).
Melton, D.W. et al., Cell, 44, 319-328 (1986).
Osborne, W.R.A. et al., Proc. Natl. Acad. Sci. USA, 85, 6851-6855 (1988).
Palella, T.D. et al., Mol. Cell. Biol., 8, 457-460 (1988).
Palella, T.D. et al., Pediatr. Res., 24, 129 (1988).
Palella, T.D. et al., Gene, 80 137-1444 (1989).
Patel, P.I. et al., Mol. Cell. Biol., 6, 393-403 (1986).
Perry, L.J. et al., J. Gen. Virol., 67, 2365-2380 (1986).
Post and Roizman, Cell, 25, 227-232 (1981).
Puga, A. et al., J. Virol., 61, 1700-1703 (1987).
Rixon, F.J. et al., J. Gen. Virol., 71, 2931-2939.
Rock, D.L. et al., J. Virol., 61, 3820-3826 (1987).
Ace, C.I. et al., J. Virol., 63: 2260-2269 (1989).
Anderson, J.R. et al., J. Neurol. Sci. 60, 181-195 (1983).
Bak, I.J. et al., Brain Res., 136, 415-429 (1977).
Bender, M.A. et al., J. Virol., 61, 1639-1646 (1987).
Boothman, D.A. et al., FEBS Lett., 258, 159-162 (1989).
Chakrabarti, et al., Mol. Cell. Bio., 5, 3403-3409 (1985).
Chiocca, E.A. et al., The New Biologist, 2, 739-746 (1990).
Clements, J.B. et al., Cell, 12, 275-285 (1977).
Cone, R.D. et al., Science, 236, 954-957 (1987).
Croen, K.D. et al., N. Engl. J. Med., 317, 1427-1432 (1987).
Deatly, A.M. et al., Proc. Natl. Acad. Sci. USA, 84, 3204-3208 (1987).
Dealty, A.M. et al. J. Virol. 62 749-756 (1988).
Dixon, R.A.F. et al., J. Virol., 36, 189-203 (1980).
Dobson, A. et al., Nueron, 5, 353-360 (1990).
Dobson, A. et al., J. Virol., 63, 3844-3851 (1989).
Rock, D.L. et al., Nature, 302, 523-525 (1983).
Sabel, B.A. et al., Soc. Neurosci. Abstr., 15, 9 (1989).
Sanes, J.R. et al., EMBO J., 5, 3133-3142 (1986).
Sauer, B. et al., Proc. Natl. Acad. Sci. USA, 84, 9108-9112 (1987).
Sederati, F. et al., J. Virol., 63, 4455-4458 (1989).
Shapira, M. et al., Nuc. Acids Res., 15, 3097-3111 (1987).
Shih, M. et al., Proc. Natl. Acad. Sci. USA, 81, 5867-5870 (1984).
Smiley, J.R. et al., J. Virol., 61, 2368-2377 (1987).
Spivack, J.G. et al., J. Virol., 61., 3841-3847 (1987).
Steiner, I. et al., EMBO J., 8, 505-511 (1989).
Stevens, J.G. et al., Science, 235, 1056-1059 (1987).
Van Zijl, M. et al., J. Gen. Virol., 71, 1747-1755 (1990).
Wagner, E.K. et al., J. Virol., 62, 1194-1202 (1988).
Wagner et al., Proc. Natl. Acad. Sci., 78, 1441-1445 (1981).
Weber, P.C. et al., Cell, 54, 369-381 (1988).
Weber, P.C. et al., Science, 236, 576-579 (1987).

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