Late differentiation antigens associated with helper T lymphocyt

Details Late differentiation antigens associated with helper T lymphocyt Late differentiation antigens associated with helper T lymphocyt

1986-02-18

1989-03-28

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Spore forming or isolating process

530387, 424 858, 435 68, 4351722, 935104, 935110, C12N 500, C07K 1504

Patent

active

048164046

ABSTRACT:
Late differentiation antigens (LDA.sub.1 and LDA.sub.2) expressed by activated helper cells are described. LDA.sub.1 and LDA.sub.2 are membrane proteins recognized by monoclonal antibodies produced by immunizing mice with alloreactive human T cell clones with helper function. LDA.sub.1 and LDA.sub.2 are expressed by helper T cells. LDA.sub.1 monoclonal antibody and LDA.sub.2 monoclonal antibody block T cell enhancement of B cell immunoglobulin production. Thus, LDA.sub.1 and LDA.sub.2 are associated with helper T cell effector function. Methods of diagnosis and therepy based upon LDA.sub.1 and LDA.sub.2 are also described.

REFERENCES:
Andreesen, R. et al, Blood, 63(6):1299-1302 (6-1984).
Feldmann, M. et al, IR Genes, Pierce, C. W. ed., Humana Press, Clifton, N.J. (1983), pp. 589-597 cited in Chemical Abstract 99:174084q.
Pilkington, G. R. et al, Pathology 16(4):447-454 (1984) cited in Biosis Abstract 85:271016.
Suciu-Foca et al., Nature, vol. 318, pp. 465-467, Dec. 5, 1985.
Suciu-Foca et al., Transplantation Proceedings, vol. XVII, No. 1, pp. 716-719, Feb. 1985.
Reed et al., Transplantation Proceedings, vol. XVII, No. 1, pp. 735-738, Feb. 1985.

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