Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1985-07-05
1989-04-04
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 4, 435 29, 435 34, 435 35, 436519, 436536, 436542, 436548, G01N 3353
Patent
active
048186899
ABSTRACT:
A late differentiation antigen (LDA.sub.1) expressed by activated helper cells is described. LDA.sub.1 is a membrane protein recognized by a monoclonal antibody produced by immunizing mice with an alloreactive human T cell clone with helper function. LDA.sub.1 is expressed by helper T cells optionally 9 days after activation. Anti-LDA.sub.1 monoclonal antibody blocks T cell enhancement of B-cell immunoglobulin production. Thus, LDA.sub.1 is associated with helper T cell effector function. Methods of diagnosis and therapy based upon LDA.sub.1 are also described.
REFERENCES:
patent: 4515895 (1985-05-01), Kung et al.
patent: 4652447 (1987-03-01), Kung et al.
patent: 4658020 (1987-04-01), Kung et al.
patent: 4677056 (1987-06-01), Dupont et al.
Cotner, et al., J. Exp. Med., vol. 157, (1983), pp. 461-472.
Haars, et al., Immunogenetics, vol. 20, (1984), pp. 397-405.
Waldmann, et al., J. Clin. Invest., vol. 73, (1984), pp. 1711-1718.
King Donald W.
Suciu-Foca Nicole
Santalone John J.
The Trustees of Columbia University in the City of New York
Warden Robert J.
White John P.
Wieder Stephen C.
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