Laser/sensitizer assisted immunotherapy

Details Laser/sensitizer assisted immunotherapy Laser/sensitizer assisted immunotherapy

1997-11-07

2000-11-21

Shay, David M.

Surgery: light, thermal, and electrical application

Light, thermal, and electrical application

Light application

606 3, 606 13, 607 88, 607 92, 604 20, A61M 506

Patent

active

061496715

ABSTRACT:
A method for treating a neoplasm, such as a malignant tumor, in humans and other animals, is disclosed. A chromophore and an immunoadjuvant are introduced into the neoplasm. The neoplasm is then lased at an irradiance sufficient to induce neoplastic cellular destruction and to stimulate the self-immunological defense system against neoplastic cellular multiplication.

REFERENCES:
patent: 4473652 (1984-09-01), Okazaki et al.
patent: 4615878 (1986-10-01), Kass
patent: 4624915 (1986-11-01), Schindler et al.
patent: 4873092 (1989-10-01), Azuma et al.
patent: 4878891 (1989-11-01), Judy et al.
patent: 5095030 (1992-03-01), Levy et al.
patent: 5169396 (1992-12-01), Dowlatshahi et al.
patent: 5198460 (1993-03-01), Pandey et al.
patent: 5214036 (1993-05-01), Allison et al.
patent: 5222953 (1993-06-01), Dowlatshahi
patent: 5238810 (1993-08-01), Fujiwara et al.
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5258453 (1993-11-01), Kopecek et al.
patent: 5266302 (1993-11-01), Peyman et al.
patent: 5283255 (1994-02-01), Levy et al.
patent: 5314905 (1994-05-01), Pandey et al.
patent: 5569240 (1996-10-01), Dowlatshahi
patent: 5576013 (1996-11-01), Williams et al.
patent: 5747475 (1998-05-01), Nordquist et al.
Amin et al. "Hepatic Metastases: Interstitial Laser Photocoagulation with Real-Time US Monitoring and Dynamic CT Evaluation of Treatment." Radiology. vol. 187, No. 2, May 1993, pp. 339-347.
Bown, S.G. "Phototherapy of Tumors." World Journal of Surgery. vol. 7, No. 6, Nov. 1983, pp. 700-709.
Dowlatshahi et al. "Stereotaxic Interstitial Laser Therapy of Early-Stage Breast Cancer." The Breast Journal. vol. 2, No. 5, 1996, pp. 304-311.
Dowlatshahi et al. "Protection of Fiber Function by Para-Axial Fluid in Interstitial Laser Therapy of Malignant Tumors." Lasers in Surgery and Medicine. vol. 10, 1990, pp. 322-327.
Dowlatshahi et al. "Histologic Evaluation of Rat Mammary Tumor Necrosis by Interstitial Nd:YAG Laser Hyperthermia." Lasers in Surgery and Medicine. vol. 12, 1992, pp. 159-164.
Harries et al. "Interstitial laser photocoagulation as a treatment for breast cancer." British Journal of Surgery. vol. 81, 1994, pp. 1617-1619.
Marble. "Breast Cancer (Therapy); Innovative Laser Therapy as a Potential Alternative to Lumpectomy." HeadsUp. Order No. 251391.
Nols.o slashed.e et al. "Interstitial Hyperthermia of Colorectal Liver Metastases with a US-guided Nd-YAG Laser with a Diffuser Tip: A Pilot Clinical Study." Radiology. vol. 187, 1993, pp. 333-337.
U.S. application No. 08/720,685, Nordquist, filed Oct. 2, 1996.
Vaccine, Mar. 1984, vol. 2, No. 2, pp. 93-99, XP002017431, Nishimura K. et al.: "Immunological activity of chitin and its derivatives."
Vaccine, 1985, vol. 3, No. 5, pp. 379-384, XP002017432, Nishimura K. et al.: "Adjuvant activity of chitin derivatives in mice and guines-pigs".
J. Control Release, 1994, vol. 29, No. 3, pp. 329-338, XP002017433, Luessen H.L. et al: "Bioadhesive polymers for the peroral delivery of peptide drugs".
WO 94 15583 A (PDT Systems Inc) Jul. 21, 1994.
Lasers in Medical Science, vol. 8, No. 3, Sep. 1, 1993, pp. 185-196, XP000575069 Folck S. T. et al: "Thermal damage of blood vessels in a rat skin-flap window chamber using indocyanine green and a pulsed alexandrite laser: a feasibility study".
Proceedings of the IEEE, vol. 80, No. 6, Jun. 1, 1992, pp. 869-889, XP0000311053, Marcus S.L.: "Photodynamic therapy of human cancer".
Lasers in Surgery and Medicine, vol. 15, No. 4, Jan. 1, 1994, pp. 342-350, XP000484642, Zhengang Yang et al.: "Tumor cell-enhanced sensitivity of vascular endothelial cells to photodynamic therapy".
Seminars in Hematology, vol. 26, No. 2, Apr. 1, 1989, pp. 157-173, XP000501369 Kreimer-Birnbaum M.: "Midified prophyrins, chlorins, phtalocyanines, and purpurins: second-generation photosensitizers for photodynamic therapy".
Database WPI, Section CH , Week 9421, Derwent Publications Ltd., London, GB; Class B04, AN 94-170527, XP00002017434 & JP 06 109 731 A (Ibiden Co Ltd), Apr. 22, 1994.
Photodynamic Therapy and Biomedical Lasers, Excerpta Medica, P. Spinelli, M. Dal Fanmte, R. Marchesini, 1992, Table of Contents and page Nos. 513-520 and 698-701.
Photodynamic Therapy--Coming of Age, Barbara W. Henderson, Photodermatology, 1989, page Nos. 200-211.

Affiliated with

Also associated with

Rating

Laser/sensitizer assisted immunotherapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Laser/sensitizer assisted immunotherapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Laser/sensitizer assisted immunotherapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1253003