Radiant energy – Ionic separation or analysis – With sample supply means
Patent
1992-03-06
1995-01-17
Dzierzynski, Paul M.
Radiant energy
Ionic separation or analysis
With sample supply means
250281, H01J 4900
Patent
active
053827937
ABSTRACT:
A laser desorption ionization instrument for measuring the molecular weight of large organic molecules includes a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer includes a sample lock for holding, under vacuum, a plurality of samples to be analyzed. A sample may be inserted into and removed from the sample lock and into the mass spectrometer without breaking vacuum in the spectrometer. Signal processing electronics of the LDIM instrument include means for identifying quasi-molecular species of a molecule being measured. The instrument includes improvements in ion optics, microchannel plate detectors, laser irradiation of samples, and preparation of samples for measurement.
REFERENCES:
patent: 4780608 (1988-10-01), Cross et al.
patent: 4988879 (1991-01-01), Zare et al.
patent: 5045694 (1991-09-01), Beavis et al.
patent: 5083020 (1992-01-01), Takahashi
Franz Hillenkamp, et al., Laser Microprobe Mass Analysis of Organic Materials, Nature, vol. 256, pp. 119-120 (Jul. 10, 1975).
R. Nitsche, et al., Mass Spectrometric Analysis of Laser Induced Microplasmas from Organic Samples, Israel Journal of Chemistry, vol. 17, pp. 181-184 (1978).
M. A. Posthumas, et al., Laser Desorption-Mass Spectrometry of Polar Nonvolatile Bio-Organic Molecules, Analytical Chemistry, vol. 50, No. 7, pp. 985-991 (Jun., 1978).
Franz Heresch, et al., Repetitive Laser Desorption Mass Spectrometry for Nonvolatile Organic Compounds, Analytical Chemistry, vol. 52, No. 12, pp. 1803-1807 (Oct. 1980).
H. J. Heinen, et al., Lamma 1000, a New Laser Microprobe Mass Analyzer for Bulk Samples, Int'l Journal of Mass Spectrometry and Ion Physics, vol. 47, pp. 19-22 (1983).
Robert J. Cotter, Lasers and Mass Spectrometry, Analytical Chemistry, vol. 56, No. 3, pp. 485A-503A (Mar., 1984).
Michael Karas, et al., Influence of the Wavelength in High-Irradiance Ultraviolet Laser Desorption Mass Spectrometry of Organic Molecules, Analytical Chemistry, vol. 57, No. 14, pp. 2935-2939 (Dec., 1985).
B. Spengler, et al., Excimer Laser Desorption Mass Spectometry of Biomolecules at 248 and 193 nm, Journal of Physical Chemistry, vol. 91, No. 26, pp. 6502-6506 (May, 1987).
Michael Karas, et al., Laser Desorption Ionization of Proteins with Molecular Masses Exceeding 10,000 Daltons, Anal. Chem, vol. 60, No. 20, pp. 2299-2301 (Oct. 15, 1988).
Koichi Tanaka, et al., Protein & Polymer Analyses up to m/z 100,000 by Laser Ionization Time-of-Flight Mass Spectometry, Proceeds of the Second Japan-China Joint Symposium on Mass Spectrometry, pp. 185-187 (1987).
Ronald Beavis, et al., Matrix-assisted Laser-desorption Mass Spectometry Using 355 nm Radiation, Rapid Communications in Mass Spectrometry, vol. 3, No. 12, pp. 436-439 (1989).
Beavis, et al., Cinnamic Acid Derivatives as Matrices for Ultraviolet Laser Desorption Mass Spectrometry of Proteins, Rapid Communications in Mass Spectrometry, vol. 3, No. 12, pp. 432-435 (1989).
M. Karas, et al., UV Laser Matrix Desorption/Ionization Mass Spectrometry of Proteins in the 100,000 Dalton Range, Int'l Journal of Mass Spectrometry and Ion Processes, vol. 92, pp. 231-242 (1989).
Beavis, et al., Factors Affecting the Ultraviolet Laser Desorption of Proteins, Rapid Communications in Mass Spectrometry, vol. 3, No. 7, pp. 233-237 (1989).
Beavis, et al., Investigations of the Matrix Assisted Laser Desorption of Proteins Using Time-of-Flight Mass Spectrometer, American Society of Mass Spectrometry Meeting Proceedings (1990).
Spengler, et al., Ultraviolet Laser Desorption/Ionization Mass Spectrometry of Proteins Above 100,000 Daltons by Pulsed Ion Extraction Time-of-Flight Analysis, Analytical Chemistry, vol. 62, No. 8, pp. 793-796 (Apr. 15, 1990).
K. O. Bornsen, et al., Analytical Applications of Matrix-assisted Laser Desorption and Ionization Mass Spectrometry, Biological Mass Spectometry, vol. 20, pp. 471-478 (1991).
M. Schar, et al., Fast Protein Sequence Determination with Matrix-Assisted Laser Desorption and Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, vol. 5, pp. 319-326 (1991).
Bornsen Klaus O.
Egan Robert W.
Gassmann Ernst
Hoppe Thomas W.
Schar Martin M.
Dzierzynski Paul M.
Hewlett--Packard Company
Nguyen Kiet T.
LandOfFree
Laser desorption ionization mass monitor (LDIM) does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Laser desorption ionization mass monitor (LDIM), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Laser desorption ionization mass monitor (LDIM) will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-748502