Laser desorption and ionization mass spectrometer with...

Details Laser desorption and ionization mass spectrometer with... Laser desorption and ionization mass spectrometer with...

2006-10-31

2006-10-31

Lee, John R. (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C250S287000, C250S300000, C250S306000, C250S307000, C250S309000

Reexamination Certificate

active

07129483

ABSTRACT:
Laser desorption/ionization time-of-flight mass spectrometer (“LDI-TOF-MS”) devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.

REFERENCES:
patent: 6580070 (2003-06-01), Cornish et al.
patent: 6833545 (2004-12-01), Axelsson
patent: 2004/0108451 (2004-06-01), Hansen
patent: 2005/0017174 (2005-01-01), Chism, II
patent: 2005/0056776 (2005-03-01), Willoughby et al.
patent: 2005/0230612 (2005-10-01), Weber
patent: 2005/0279929 (2005-12-01), Youngquist et al.

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